Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Efficient Multicomponent Synthesis of 1,2,3-Triazoles Catalyzed by Cu(Ii) Supported on Pei@Fe3o4 Mnps in a Water/Peg300 System Publisher



Hasanpour Z1 ; Maleki A2 ; Hosseini M3 ; Gorgannezhad L4 ; Nejadshafiee V5 ; Ramazani A1 ; Haririan I6 ; Shafiee A5 ; Khoobi M5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Chemistry, University of Zanjan, Zanjan, Iran
  2. 2. Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan, Iran
  3. 3. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
  4. 4. Department of Biology, Faculty of Science, Payame Noor University, Iran
  5. 5. Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Turkish Journal of Chemistry Published:2017


Abstract

A highly dispersible and magnetically recoverable Cu-PEI@Fe3O4 MNPs catalyst was prepared and success-fully applied in one-pot three-component coupling of terminal alkynes, sodium azide, and alkyl bromides/chlorides in water to give 1,4-disubstituted 1,2,3-triazoles with good to excellent yields. The catalyst was fully characterized with FT-IR, TGA, TEM, SEM, VSM, EDX, cyclic voltammetry, and ICP-AES spectroscopic techniques. Furthermore, the catalyst was easily recycled by an external magnet and successfully reused six times in the reaction without significant loss of its catalytic activity and copper leaching. The large-scale reaction was also carried out in the absence of any base and reducing agent even with 0.1 mol% of the catalyst in aqueous media, making this protocol a good candidate for practical applications.