The Usefulness of Immunotherapy in Pediatric Neurodegenerative Disorders: A Systematic Review of Literature Data

The Usefulness of Immunotherapy in Pediatric Neurodegenerative Disorders: A Systematic Review of Literature Data Publisher Pubmed

Vitaliti G¹ ; Tabatabaie O² ; Matin N² ; Ledda C³ ; Pavone P¹ ; Lubrano R⁴ ; Serra A⁵ ; Di Mauro P⁵ ; Cocuzza S⁵ ; Falsaperla R¹

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1. Acute and Emergency Paediatric and General Paediatric Operative Unit, Policlinico-Vittorio Emanuele Hospital, University of Catania, Catania, Italy
2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Hygiene and Public Health, Department of Medical, Surgical Sciences and Advanced Technologies G.F. Ingrassia, University of Catania, Catania, Italy
4. Pediatric Department, Pediatric Nephrology Operative Unit of the Sapienza University of Rome, Rome, Italy
5. ENT Department G.F. Ingrassia, Policlinico-Vittorio Emanuele University Hospital, University of Catania, Catania, Italy

Source: Human Vaccines and Immunotherapeutics Published:2015

Abstract

Immunotherapeutic strategies to treat neurodegenerative disorders have inspired the scientific community. The aim of our review is to address the translational aspects of neuroimmunology to describe the efficacy of immunotherapy in the treatment of pediatric neurodegenerative disorders. In the studies we analyzed IVIG were found to be efficient in the treatment of post-streptococcal neurodegenerative disorders, even if in PANDAS, plasma-exchange (PE) showed a higher efficiency. IVIG were also successfully used in ADEM and Guillan-Barre syndrome. In Sydenham Chorea the use of methylprednisolone was found in most cases as efficient as IVIG, while in Tourette’s Syndrome, Colecoxib was successfully used in one patient. Pediatric Multiple Sclerosis seems to respond better to immunosuppressant agents (Mitoxantrone, Cyclophosphamide, Natalizumab), as well as Neuromyelitis optica (Rituximab, Mycofenolate). The importance of this review relies in the attempt to draw standardized guidelines for immunotherapy in pediatric neurodegeneratve disorders ©2015 Taylor & Francis Group, LLC.

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Style	Citing Format
MLA	Vitaliti G, et al.. "The Usefulness of Immunotherapy in Pediatric Neurodegenerative Disorders: A Systematic Review of Literature Data." Human Vaccines and Immunotherapeutics, vol. 11, no. 12, 2015, pp. 2749-2763.
APA	Vitaliti G, Tabatabaie O, Matin N, Ledda C, Pavone P, Lubrano R, Serra A, Di Mauro P, Cocuzza S, Falsaperla R (2015). The Usefulness of Immunotherapy in Pediatric Neurodegenerative Disorders: A Systematic Review of Literature Data. Human Vaccines and Immunotherapeutics, 11(12), 2749-2763.
Chicago	Vitaliti G, Tabatabaie O, Matin N, Ledda C, Pavone P, Lubrano R, Serra A, Di Mauro P, Cocuzza S, Falsaperla R. "The Usefulness of Immunotherapy in Pediatric Neurodegenerative Disorders: A Systematic Review of Literature Data." Human Vaccines and Immunotherapeutics 11, no. 12 (2015): 2749-2763.
Harvard	Vitaliti G et al. (2015) 'The Usefulness of Immunotherapy in Pediatric Neurodegenerative Disorders: A Systematic Review of Literature Data', Human Vaccines and Immunotherapeutics, 11(12), pp. 2749-2763.
Vancouver	Vitaliti G, Tabatabaie O, Matin N, Ledda C, Pavone P, Lubrano R, et al.. The Usefulness of Immunotherapy in Pediatric Neurodegenerative Disorders: A Systematic Review of Literature Data. Human Vaccines and Immunotherapeutics. 2015;11(12):2749-2763.
BibTex	@article{ author = {Vitaliti G and Tabatabaie O and Matin N and Ledda C and Pavone P and Lubrano R and Serra A and Di Mauro P and Cocuzza S and Falsaperla R}, title = {The Usefulness of Immunotherapy in Pediatric Neurodegenerative Disorders: A Systematic Review of Literature Data}, journal = {Human Vaccines and Immunotherapeutics}, volume = {11}, number = {12}, pages = {2749-2763}, year = {2015} }
RIS	TY - JOUR AU - Vitaliti G AU - Tabatabaie O AU - Matin N AU - Ledda C AU - Pavone P AU - Lubrano R AU - Serra A AU - Di Mauro P AU - Cocuzza S AU - Falsaperla R TI - The Usefulness of Immunotherapy in Pediatric Neurodegenerative Disorders: A Systematic Review of Literature Data JO - Human Vaccines and Immunotherapeutics VL - 11 IS - 12 SP - 2749 EP - 2763 PY - 2015 ER -

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