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The Impact of Epithelial-Mesenchymal Transition (Emt) Induced by Metabolic Processes and Intracellular Signaling Pathways on Chemo-Resistance, Metastasis, and Recurrence in Solid Tumors Publisher Pubmed



Liaghat M1, 2 ; Ferdousmakan S3 ; Mortazavi SH4 ; Yahyazadeh S5 ; Irani A6 ; Banihashemi S7 ; Seyedi Asl FS8 ; Akbari A2, 9 ; Farzam F10 ; Aziziyan F2, 10 ; Bakhtiyari M2, 11 ; Arghavani MJ12 ; Zalpoor H2, 9 ; Nabiafjadi M10
Authors
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Authors Affiliations
  1. 1. Department of Medical Laboratory Sciences, Faculty of Medical Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran
  2. 2. Network of Immunity in Infection, Malignancy & Autoimmunity (NIIMA), Universal Scientific Education & Research Network (USERN), Tehran, Iran
  3. 3. Department of Pharmacy Practice, Nargund College of Pharmacy, Bangalore, 560085, India
  4. 4. Neurosurgery Department of Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Immunology, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Biology, Faculty of Basic Sciences, University of Guilan, Rasht, Iran
  7. 7. Department of Bioscience, School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom
  8. 8. Medical School, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  10. 10. Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  11. 11. Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  12. 12. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran

Source: Cell Communication and Signaling Published:2024


Abstract

The intricate cellular process, known as the epithelial-mesenchymal transition (EMT), significantly influences solid tumors development. Changes in cell shape, metabolism, and gene expression linked to EMT facilitate tumor cell invasion, metastasis, drug resistance, and recurrence. So, a better understanding of the intricate processes underlying EMT and its role in tumor growth may lead to the development of novel therapeutic approaches for the treatment of solid tumors. This review article focuses on the signals that promote EMT and metabolism, the intracellular signaling pathways leading to EMT, and the network of interactions between EMT and cancer cell metabolism. Furthermore, the functions of EMT in treatment resistance, recurrence, and metastasis of solid cancers are covered. Lastly, treatment approaches that focus on intracellular signaling networks and metabolic alterations brought on by EMT will be discussed. © The Author(s) 2024.
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