Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Metastatic Outgrowth Via the Two-Way Interplay of Autophagy and Metabolism Publisher Pubmed



Behrooz AB1, 2 ; Cordani M3, 4 ; Donadelli M5 ; Ghavami S1, 6, 7, 8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Human Anatomy and Cell Science, University of Manitoba College of Medicine, Winnipeg, MB, Canada
  2. 2. Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain
  4. 4. Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid, Spain
  5. 5. Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, Verona, Italy
  6. 6. Academy of Silesia, Faculty of Medicine, Rolna 43 Street, Katowice, 40-555, Poland
  7. 7. Department of Biomedical Engineering, University of Manitoba, Winnipeg, MB, Canada
  8. 8. Research Institute of Oncology and Hematology, Cancer Care Manitoba-University of Manitoba, Winnipeg, MB, Canada

Source: Biochimica et Biophysica Acta - Molecular Basis of Disease Published:2024


Abstract

Metastasis represents one of the most dangerous issue of cancer progression, characterized by intricate interactions between invading tumor cells, various proteins, and other cells on the way towards target sites. Tumor cells, while undergoing metastasis, engage in dynamic dialogues with stromal cells and undertake epithelial-mesenchymal transition (EMT) phenoconversion. To ensure survival, tumor cells employ several strategies such as restructuring their metabolic needs to adapt to the alterations of the microenvironmental resources via different mechanisms including macroautophagy (autophagy) and to circumvent anoikis—a form of cell death induced upon detachment from the extracellular matrix (ECM). This review focuses on the puzzling connections of autophagy and energetic metabolism within the context of cancer metastasis. © 2023 Elsevier B.V.
Related Docs
1. Recent Advances in Glioblastoma Multiforme Therapy: A Focus on Autophagy Regulation, Biomedicine and Pharmacotherapy (2022)
2. The Obesity-Autophagy-Cancer Axis: Mechanistic Insights and Therapeutic Perspectives, Seminars in Cancer Biology (2024)
3. Autophagy Induced by Metabolic Processes Leads to Solid Tumor Cell Metastatic Dormancy and Recurrence, Medical Oncology (2025)
4. Targeting Autophagy in Prostate Cancer: Preclinical and Clinical Evidence for Therapeutic Response, Journal of Experimental and Clinical Cancer Research (2022)
5. Tumor Immunology, Clinical Immunology (2022)
6. Cross-Talk Between Non-Ionizing Electromagnetic Fields and Metastasis; Emt and Hybrid E/M May Explain the Anticancer Role of Emfs, Progress in Biophysics and Molecular Biology (2023)
7. The Role of Autophagy in Cancer: From Molecular Mechanism to Therapeutic Window, Frontiers in Immunology (2025)
8. The Multifaceted Role of Extracellular Vesicles (Evs) in Colorectal Cancer: Metastasis, Immune Suppression, Therapy Resistance, and Autophagy Crosstalk, Journal of Translational Medicine (2024)
Experts (# of related papers)
Nima Rezaei (2)
Zahra Salehi (1)