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Association of Serum Omentin Levels With Microvascular Complications of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis Publisher



Kazemzadeh K1 ; Bayani M2 ; Khademi R3 ; Sadatmadani SF4 ; Habibzadeh A5, 6 ; Shirani M2 ; Ghadri H7 ; Abbasalizadeh M8 ; Izadi E9 ; Rezaee M2 ; Shafiei A2 ; Joudaki A2 ; Asadigandomani H10 ; Deravi N2 Show All Authors
Authors
  1. Kazemzadeh K1
  2. Bayani M2
  3. Khademi R3
  4. Sadatmadani SF4
  5. Habibzadeh A5, 6
  6. Shirani M2
  7. Ghadri H7
  8. Abbasalizadeh M8
  9. Izadi E9
  10. Rezaee M2
  11. Shafiei A2
  12. Joudaki A2
  13. Asadigandomani H10
  14. Deravi N2
  15. Meybodi SM11
  16. Bafrani MA1
Show Affiliations
Authors Affiliations
  1. 1. Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  4. 4. School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  6. 6. USERN Office, Fasa University of Medical Sciences, Fasa, Iran
  7. 7. School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  8. 8. School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
  10. 10. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2023


Abstract

Background and aims: Type 2 diabetes mellitus (T2DM) is a chronic condition associated with various microvascular complications, including neuropathy, retinopathy, and nephropathy. Recent studies have suggested a potential association between serum omentin levels and the risk of developing microvascular complications in patients with T2DM. However, the existing evidence remains inconclusive. Therefore, we conducted a systematic review and meta-analysis to examine the association between serum omentin levels and microvascular complications in T2DM patients. Methods: A comprehensive search was conducted in PubMed, Scopus, and Google Scholar databases to retrieve relevant articles published up to May 2023. Observational studies investigating omentin levels association with microvascular complications in T2DM patients were included. Data was extracted and hence analyzed. Results: A total of seven cross-sectional articles met the inclusion criteria, with a total population of 1587 participants. The meta-analysis revealed a significant association between serum omentin levels and microvascular complications in patients with T2DM. Serum omentin levels were lower in patients with microvascular complications than in those without complications (Mean difference, 95% confidence interval: -1.31 [-2.50, -0.13], I2 = 99.62%). Conclusion: This systematic review and meta-analysis provides evidence supporting an association between serum omentin levels and microvascular complications in patients with T2DM. The findings suggest that Omentin may be lower in T2DM patients with microvascular complications. Further research is warranted to elucidate the underlying mechanisms and explore the clinical implications of these findings. © 2023, The Author(s), under exclusive licence to Tehran University of Medical Sciences.
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