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Alcohol Intake and Gastric Cancer: Meta-Analyses of Published Data Versus Individual Participant Data Pooled Analyses (Stop Project) Publisher Pubmed



Ferro A1 ; Morais S1 ; Rota M3, 4 ; Pelucchi C4 ; Bertuccio P4 ; Bonzi R4 ; Galeone C4 ; Zhang ZF5 ; Matsuo K6 ; Ito H6 ; Hu J7 ; Johnson KC8 ; Yu GP9 ; Palli D10 Show All Authors
Authors
  1. Ferro A1
  2. Morais S1
  3. Rota M3, 4
  4. Pelucchi C4
  5. Bertuccio P4
  6. Bonzi R4
  7. Galeone C4
  8. Zhang ZF5
  9. Matsuo K6
  10. Ito H6
  11. Hu J7
  12. Johnson KC8
  13. Yu GP9
  14. Palli D10
  15. Ferraroni M4
  16. Muscat J11
  17. Malekzadeh R12
  18. Ye W13
  19. Song H13, 14
  20. Zaridze D15
  21. Maximovitch D15
  22. Fernandez De Larrea N16, 17
  23. Kogevinas M17, 18, 19, 20
  24. Vioque J21
  25. Navarretemunoz EM21
  26. Pakseresht M12, 22, 23
  27. Pourfarzi F12, 24
  28. Wolk A25, 35
  29. Orsini N25
  30. Bellavia A25
  31. Hakansson N25
  32. Mu L26
  33. Pastorino R27
  34. Kurtz RC29
  35. Derakhshan MH12, 30
  36. Lagiou A31
  37. Lagiou P32, 33
  38. Boffetta P34
  39. Boccia S27
  40. Negri E3
  41. La Vecchia C4
  42. Peleteiro B1, 2
  43. Lunet N1, 2
Show Affiliations
Authors Affiliations
  1. 1. EPIUnit - Instituto de Saude Publica, Universidade do Porto, Rua das Taipas, nº 135, Porto, 4050-600, Portugal
  2. 2. Departamento de Ciencias da Saude Publica e Forenses e Educacao Medica, Faculdade de Medicina, Universidade do Porto, Al. Prof. Hernani Monteiro, Porto, 4200-319, Portugal
  3. 3. Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy
  4. 4. Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy
  5. 5. Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, United States
  6. 6. Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
  7. 7. Department of Epidemiology, Harbin Medical University, Harbin, China
  8. 8. School of Epidemiology, Public Health and Preventive Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
  9. 9. Medical Informatics Center, Peking University, Peking, China
  10. 10. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - Istituto per lo Studio e la Prevenzione Oncologica (ISPO), Florence, Italy
  11. 11. Department of Public Health Sciences, The Pennsylvania State University College of Medicine, Penn State Hershey Medical Center, Hershey, PA, United States
  12. 12. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  13. 13. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  14. 14. Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  15. 15. Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russian Federation
  16. 16. Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain
  17. 17. CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain
  18. 18. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain
  19. 19. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
  20. 20. Universitat Pompeu Fabra (UPF), Barcelona, Spain
  21. 21. Miguel Hernandez University and ISABIAL-FISABIO Foundation, Campus San Juan, Alicante, Spain
  22. 22. Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada
  23. 23. Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
  24. 24. Digestive Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  25. 25. Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  26. 26. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United States
  27. 27. Section of Hygiene - Institute of Public Health
  28. 28. Universita Cattolica del Sacro Cuore, IRCCS Fondazione Policlinico “Agostino Gemelli�, L.go F. Vito, Rome, 1-00168, Italy
  29. 29. Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York, NY, United States
  30. 30. Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, United Kingdom
  31. 31. Department of Public Health and Community Health, School of Health Professions, Athens Technological Educational Institute, Athens, Greece
  32. 32. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
  33. 33. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  34. 34. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  35. 35. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

Source: Cancer Epidemiology Published:2018


Abstract

Background: Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer. Methods: We compared estimates obtained from conventional meta-analyses, using only data available in published reports from studies that take part in the Stomach Cancer Pooling (StoP) Project, with individual participant data pooled analyses including the same studies. Results: A total of 22 studies from the StoP Project assessed the relation between alcohol intake and gastric cancer, 19 had specific data for levels of consumption and 18 according to cancer location; published reports addressing these associations were available from 18, 5 and 5 studies, respectively. The summary odds ratios [OR, (95%CI)] estimate obtained with published data for drinkers vs. non-drinkers was 10% higher than the one obtained with individual StoP data [18 vs. 22 studies: 1.21 (1.07–1.36) vs. 1.10 (0.99–1.23)] and more heterogeneous (I 2 : 63.6% vs 54.4%). In general, published data yielded less precise summary estimates (standard errors up to 2.6 times higher). Funnel plot analysis suggested publication bias. Conclusion: Meta-analyses of the association between alcohol drinking and gastric cancer tended to overestimate the magnitude of the effects, possibly due to publication bias. Additionally, individual participant data pooled analyses yielded more precise estimates for different levels of exposure or cancer subtypes. © 2018 Elsevier Ltd
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