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An Update on Nanoparticle-Based Contrast Agents in Medical Imaging Publisher Pubmed



Naseri N1 ; Ajorlou E2 ; Asghari F1 ; Pilehvarsoltanahmadi Y3, 4
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2018


Abstract

Despite the great value of current exogenous contrast agents for providing main diagnostic information, they still have certain drawbacks such as short blood half life, nonspecific biodistribution, fast clearance, slight renal toxicity and poor contrast in fat patients. Nanoparticles (NPs) are used as novel contrast agents that represent a promising strategy for the non invasive diagnosis. As a platform, nanoparticulates are compatible for developing targeted contrast agents. Advances in nanotechnology will provide enhanced sensitivity and specificity for tumor imaging enabling earlier detection of metastases. This article focuses on fundamental issue such as biological interactions, clearance routes, coating of NPs and presents a wide discussion about most recent category of NPs that are used as contrast agents and thebenefits/concerns issues associated with their use in clinical procedures. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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