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Interactions Dietary Components With Expression Level of Breast Cancer-Related Genes Publisher



Bourbour F1 ; Pourtaheri A2 ; Abbasi K3 ; Hasanpour Ardekanizadeh N9 ; Gholamalizadeh M4 ; Hajipour A5 ; Abdollahi S7 ; Bagheri SE8 ; Ahmadzadeh M1 ; Doaei S6, 10 ; Haghighian A10
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of Nutrition, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Food Security Research Center and Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. School of Health, Qazvin University of Medical Sciences, Qazvin, Iran
  6. 6. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Medical Genetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  8. 8. School of Health, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  9. 9. Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran
  10. 10. Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Egyptian Journal of Medical Human Genetics Published:2022


Abstract

Background: Dietary components can influence the effects of genetic background in breast cancer (BC). This review study aimed to investigate the effect of dietary components on the expression level of BC-related genes. Methods: In this narrative review, Embase, PubMed, PsycInfo, and the Cochrane databases were used to collect the related papers with interactions of BC, genetics, and dietary intake. Appropriate keywords such as BC, gene expression, mutation, nutrient, and diet (alone and together) were applied for data collection. Results: The association of BC with some genes including the BC1 gene (BRCA1), the human epidermal growth factor receptor 2 (HER2), and the fat mass and obesity-associated (FTO) gene can be affected by dietary components. Moderate B12 supplementation may be protective against BC in people with the inherited mutation of BRCA. The olive oil may have a protective effect against BC through several mechanisms such as suppressing HER-2 expression. Furthermore, high glycemic index foods may increase the risk of BC by the activation of the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway and the up-regulation of FTO gene expression. Conclusion: There are interactions between BC, BC-related genes, and dietary intake. Dietary components such as macronutrients, micronutrients, and phytochemicals may regulate the expression level of BC-related genes. Further longitudinal studies are needed to confirm the associations between BC-related genes and diet and to discover the underlying mechanisms. © 2022, The Author(s).
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