The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake

The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake Publisher

Gholamalizadeh M¹ ; Jonoush M² ; Mobarakeh KA³ ; Amjadi A⁴ ; Alami F⁵ ; Valisoltani N⁶ ; Askarpour SA⁷ ; Azizitabesh G⁸ ; Mohammadian MK⁹ ; Akbari ME¹ ; Rajabibazl M¹⁰ ; Alemrajabi M¹¹ ; Poodineh J¹² ; Sadeghi H⁸ Show All Authors

Gholamalizadeh M¹
Jonoush M²
Mobarakeh KA³
Amjadi A⁴
Alami F⁵
Valisoltani N⁶
Askarpour SA⁷
Azizitabesh G⁸
Mohammadian MK⁹
Akbari ME¹
Rajabibazl M¹⁰
Alemrajabi M¹¹
Poodineh J¹²
Sadeghi H⁸
Hosseinzadeh P¹³
Dahka SM¹⁴
Badeli M¹⁵
Jarrahi SAM¹⁶
Doaei S¹⁷

Show Affiliations

1. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
4. Department of Nutrition, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
5. Student Research Committee, Department of Nutrition, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
6. Department of Clinical Nutrition, School of Nutrition Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
7. Division of Food Safety and Hygiene, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
8. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
9. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
10. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
11. Clinical Research Development Center (CRDC), Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Zabol, Iran
12. Department of Clinical Biochemistry, School of Medicine, Zabol University of Medical Sciences, Tehran, Iran
13. Gastrointestinal and Liver Diseases Research Center (GLDRC), Iran University of Medical Sciences, Tehran, Iran
14. School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
15. Department of Nutrition, Urmia University of Medical Science, Urmia, Iran
16. Department of Social Medicine, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
17. Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Frontiers in Nutrition Published:2023

Abstract

Background: FTO gene is associated with obesity, dietary intake, and the risk of colorectal cancer (CRC). In this study, patients with colorectal cancer were assessed for the interactions between FTO gene polymorphisms and dietary intake. Methods: This case–control study was carried out on 450 participants aged 35–70 years including 150 patients with colorectal cancer and 300 healthy controls. Blood samples were collected in order to extract DNA and genotyping of FTO gene for rs9939609 polymorphism. A validated 168-item food frequency questionnaire (FFQ) and the Nutritionist-IV software were used to assess dietary intake. Results: In the participants with the TT genotype of FTO rs9939609 polymorphism, CRC risk was significantly associated with higher intake of dietary fat (OR:1.87 CI95%:1.76–1.99, p = 0.04), vitamin B3 (OR:1.20 CI95%:1.08–1.65, p = 0.04), and vitamin C (OR:1.06 CI95%:1.03–1.15, p = 0.04) and lower intake of β-carotene (OR:0.98 CI95%:0.97–0.99, p = 0.03), vitamin E (OR:0.77 CI95%:0.62–0.95, p = 0.02), vitamin B1 (OR:0.15 CI95%:0.04–0.50, p < 0.01), and biotin (OR:0.72 CI95%:0.0.57–0.92, p = 0.01). No significant association was found between CRC and dietary intake in carriers of AA/AT genotypes after adjustments for the confounders. Conclusion: CRC risk may be decreased by β-carotene, vitamins E, B1, and biotin only in those without the risk allele of the FTO gene. The association of CRC and diet may be influenced by FTO genotype. Further studies are warranted. Copyright © 2023 Gholamalizadeh, Jonoush, Mobarakeh, Amjadi, Alami, Valisoltani, Askarpour, Azizi-Tabesh, Mohammadian, Akbari, Rajabibazl, Alemrajabi, Poodineh, Sadeghi, Hosseinzadeh, Dahka, Badeli, Jarrahi and Doaei.

Related Docs

View other Related Docs

1. The Effect of Fto Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Fiber, Frontiers in Nutrition (2022)

2. The Association Between Different Types of Dietary Carbohydrates and Colorectal Cancer: A Case-Control Study, Frontiers in Nutrition (2022)

3. Unraveling the Complex Interactions Between the Fat Mass and Obesity-Associated (Fto) Gene, Lifestyle, and Cancer, Advances in Nutrition (2022)

4. Colorectal Cancer: Epidemiology, Risk Factors, and Prevention, Cancers (2024)

5. Dietary Ruminant and Industrial Trans-Fatty Acids Intake and Colorectal Cancer Risk, Nutrients (2022)

6. Association Between Dietary Intake of Fatty Acids and Colorectal Cancer, a Case-Control Study, Frontiers in Nutrition (2022)

7. Dietary Glycemic Index and Glycemic Load Mediate the Effect of Cartpt Rs2239670 Gene Polymorphism on Metabolic Syndrome and Metabolic Risk Factors Among Adults With Obesity, BMC Endocrine Disorders (2022)

8. Dietary Choline and Betaine Intake and Risk of Colorectal Cancer in an Iranian Population, Cancers (2023)

Experts (# of related papers)

View all Related Experts

Kazem Zendehdel (13)

Reza Malekzadeh (10)

Style	Citing Format
MLA	Gholamalizadeh M, et al.. "The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake." Frontiers in Nutrition, vol. 10, no. , 2023, pp. -.
APA	Gholamalizadeh M, Jonoush M, Mobarakeh KA, Amjadi A, Alami F, Valisoltani N, Askarpour SA, Azizitabesh G, Mohammadian MK, Akbari ME, Rajabibazl M, Alemrajabi M, Poodineh J, Sadeghi H, Hosseinzadeh P, Dahka SM, Badeli M, Jarrahi SAM, Doaei S (2023). The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake. Frontiers in Nutrition, 10(), -.
Chicago	Gholamalizadeh M, Jonoush M, Mobarakeh KA, Amjadi A, Alami F, Valisoltani N, Askarpour SA, et al.. "The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake." Frontiers in Nutrition 10, no. (2023): -.
Harvard	Gholamalizadeh M et al. (2023) 'The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake', Frontiers in Nutrition, 10(), pp. -.
Vancouver	Gholamalizadeh M, Jonoush M, Mobarakeh KA, Amjadi A, Alami F, Valisoltani N, et al.. The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake. Frontiers in Nutrition. 2023;10():-.
BibTex	@article{ author = {Gholamalizadeh M and Jonoush M and Mobarakeh KA and Amjadi A and Alami F and Valisoltani N and Askarpour SA and Azizitabesh G and Mohammadian MK and Akbari ME and Rajabibazl M and Alemrajabi M and Poodineh J and Sadeghi H and Hosseinzadeh P and Dahka SM and Badeli M and Jarrahi SAM and Doaei S}, title = {The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake}, journal = {Frontiers in Nutrition}, volume = {10}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Gholamalizadeh M AU - Jonoush M AU - Mobarakeh KA AU - Amjadi A AU - Alami F AU - Valisoltani N AU - Askarpour SA AU - Azizitabesh G AU - Mohammadian MK AU - Akbari ME AU - Rajabibazl M AU - Alemrajabi M AU - Poodineh J AU - Sadeghi H AU - Hosseinzadeh P AU - Dahka SM AU - Badeli M AU - Jarrahi SAM AU - Doaei S TI - The Effects of Fto Gene Rs9939609 Polymorphism on the Association Between Colorectal Cancer and Dietary Intake JO - Frontiers in Nutrition VL - 10 IS - SP - EP - PY - 2023 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract