Exosomal Micrornas Derived From Mesenchymal Stem Cells: Cell-To-Cell Messages Publisher Pubmed



Asgarpour K¹ ; Shojaei Z² ; Amiri F³ ; Ai J⁴ ; Mahjoubintehran M^{5, 6} ; Ghasemi F⁷ ; Arefnezhad R⁸ ; Hamblin MR⁹ ; Mirzaei H¹⁰
Source: Cell Communication and Signaling Published:2020

Abstract

Exosomes are extracellular vesicles characterized by their size, source, release mechanism and contents. MicroRNAs (miRNAs) are single stranded non-coding RNAs transcribed from DNA. Exosomes and miRNAs are widespread in eukaryotic cells, especially in mesenchymal stem cells (MSCs). MSCs are used for tissue regeneration, and also exert paracrine, anti-inflammatory and immunomodulatory effects. However, the use of MSCs is controversial, especially in the presence or after the remission of a tumor, due to their secretion of growth factors and their migration ability. Instead of intact MSCs, MSC-derived compartments or substances could be used as practical tools for diagnosis, follow up, management and monitoring of diseases. Herein, we discuss some aspects of exosomal miRNAs derived from MSCs in the progression, diagnosis and treatment of various diseases. [MediaObject not available: see fulltext.] © 2020 The Author(s).