The Analysis of Association Between Snca, Huseyo and Csmd1 Gene Variants and Parkinson’S Disease in Iranian Population

The Analysis of Association Between Snca, Huseyo and Csmd1 Gene Variants and Parkinson’S Disease in Iranian Population Publisher Pubmed

Shahmohammadibeni N¹ ; Rahimialiabadi S² ; Jamshidi J³ ; Emamalizadeh B² ; Shahmohammadibeni HA⁴ ; Zare Bidoki A⁵ ; Akhavanniaki H¹ ; Eftekhari H¹ ; Abdollahi S⁶ ; Shekari Khaniani M^{7, 8} ; Shahmohammadibeni M¹ ; Fazeli A² ; Motallebi M² ; Taghavi S² Show All Authors

Shahmohammadibeni N¹
Rahimialiabadi S²
Jamshidi J³
Emamalizadeh B²
Shahmohammadibeni HA⁴
Zare Bidoki A⁵
Akhavanniaki H¹
Eftekhari H¹
Abdollahi S⁶
Shekari Khaniani M^{7, 8}
Shahmohammadibeni M¹
Fazeli A²
Motallebi M²
Taghavi S²
Ahmadifard A²
Shafiei Zarneh AE²
Andarva M²
Dadkhah T¹
Khademi E¹
Alehabib E²
Rahimi M²
Tafakhori A⁹
Atakhorrami M²
Darvish H²

Show Affiliations

1. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran
2. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
4. Neurology Department, Jondi-Shapoor University of Medical Sciences, Ahwaz, Iran
5. Thrombosis Hemostasis Research Center, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
7. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
8. Neurosceinces Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
9. Department of Neurology, School of Medicine, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran

Source: Neurological Sciences Published:2016

Abstract

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder. Both genetic and environmental factors are involved in the etiology of the disease. Many studies have revealed the susceptibility genes and variations for PD which need further confirmation. Here we evaluated the association of variations in SNCA, HUSEYO and CSMD1 genes with PD. A case–control study was conducted with 489 PD patients and 489 healthy controls. DNA was extracted from peripheral blood of all subjects and rs356220 and rs11931074 in SNCA, rs2338971 in HUSEYO and rs12681349 in CSMD1 were genotyped using PCR–RFLP method. The genotypes and allele frequencies were significantly different between case and control groups for rs356220, rs11931074 and rs2338971 but not for rs12681349. We provided further evidence that rs356220 is associated with increased risk of PD supporting previous studies in Caucasian-based and Japanese populations. The association of rs11931074 with decreased risk of PD was also significant. This study revealed the first evidence of the association of rs2338971 with increased risk of PD in the Iranian population. Nevertheless, these findings need further validation via more replication studies. © 2016, Springer-Verlag Italia.

2. Genetic Analysis of the Znf512b, Slc41a1, and Aldh2 Polymorphisms in Parkinson's Disease in the Iranian Population, Genetic Testing and Molecular Biomarkers (2016)

3. Olfactory Dysfunction As a Diagnostic and Prognostic Marker for Movement Disorders, Annals of Movement Disorders (2024)

4. Exploring for Self-Care Process in Patients With Parkinson's Disease: A Grounded Theory Study, HAYAT (2015)

5. Sipa1l2, Mir4697, Gch1 and Vps13c Loci and Risk of Parkinson's Diseases in Iranian Population: A Case-Control Study, Journal of the Neurological Sciences (2016)

Experts (# of related papers)

Abbas Tafakhori (3)

Reza Negarandeh (1)

Style	Citing Format
MLA	Shahmohammadibeni N, et al.. "The Analysis of Association Between Snca, Huseyo and Csmd1 Gene Variants and Parkinson’S Disease in Iranian Population." Neurological Sciences, vol. 37, no. 5, 2016, pp. 731-736.
APA	Shahmohammadibeni N, Rahimialiabadi S, Jamshidi J, Emamalizadeh B, Shahmohammadibeni HA, Zare Bidoki A, Akhavanniaki H, Eftekhari H, Abdollahi S, Shekari Khaniani M, Shahmohammadibeni M, Fazeli A, Motallebi M, Taghavi S, Ahmadifard A, Shafiei Zarneh AE, Andarva M, Dadkhah T, Khademi E, ... Darvish H (2016). The Analysis of Association Between Snca, Huseyo and Csmd1 Gene Variants and Parkinson’S Disease in Iranian Population. Neurological Sciences, 37(5), 731-736.
Chicago	Shahmohammadibeni N, Rahimialiabadi S, Jamshidi J, Emamalizadeh B, Shahmohammadibeni HA, Zare Bidoki A, Akhavanniaki H, et al.. "The Analysis of Association Between Snca, Huseyo and Csmd1 Gene Variants and Parkinson’S Disease in Iranian Population." Neurological Sciences 37, no. 5 (2016): 731-736.
Harvard	Shahmohammadibeni N et al. (2016) 'The Analysis of Association Between Snca, Huseyo and Csmd1 Gene Variants and Parkinson’S Disease in Iranian Population', Neurological Sciences, 37(5), pp. 731-736.
Vancouver	Shahmohammadibeni N, Rahimialiabadi S, Jamshidi J, Emamalizadeh B, Shahmohammadibeni HA, Zare Bidoki A, et al.. The Analysis of Association Between Snca, Huseyo and Csmd1 Gene Variants and Parkinson’S Disease in Iranian Population. Neurological Sciences. 2016;37(5):731-736.
BibTex	@article{ author = {Shahmohammadibeni N and Rahimialiabadi S and Jamshidi J and Emamalizadeh B and Shahmohammadibeni HA and Zare Bidoki A and Akhavanniaki H and Eftekhari H and Abdollahi S and Shekari Khaniani M and Shahmohammadibeni M and Fazeli A and Motallebi M and Taghavi S and Ahmadifard A and Shafiei Zarneh AE and Andarva M and Dadkhah T and Khademi E and Alehabib E and Rahimi M and Tafakhori A and Atakhorrami M and Darvish H}, title = {The Analysis of Association Between Snca, Huseyo and Csmd1 Gene Variants and Parkinson’S Disease in Iranian Population}, journal = {Neurological Sciences}, volume = {37}, number = {5}, pages = {731-736}, year = {2016} }
RIS	TY - JOUR AU - Shahmohammadibeni N AU - Rahimialiabadi S AU - Jamshidi J AU - Emamalizadeh B AU - Shahmohammadibeni HA AU - Zare Bidoki A AU - Akhavanniaki H AU - Eftekhari H AU - Abdollahi S AU - Shekari Khaniani M AU - Shahmohammadibeni M AU - Fazeli A AU - Motallebi M AU - Taghavi S AU - Ahmadifard A AU - Shafiei Zarneh AE AU - Andarva M AU - Dadkhah T AU - Khademi E AU - Alehabib E AU - Rahimi M AU - Tafakhori A AU - Atakhorrami M AU - Darvish H TI - The Analysis of Association Between Snca, Huseyo and Csmd1 Gene Variants and Parkinson’S Disease in Iranian Population JO - Neurological Sciences VL - 37 IS - 5 SP - 731 EP - 736 PY - 2016 ER -

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