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Efficacy of a Topical Herbal Cream Containing Frankincense Oil, Pumpkin Oil and Licorice Aqueous Extract in Patients With Mild-To-Moderate Plaque Psoriasis: A Randomized Clinical Trial Publisher



Fadaei F1 ; Ayati MH1 ; Firooz A2 ; Younespour S3 ; Abouali M4 ; Tabarrai M1 ; Shirbeigi L1
Authors

Source: Research Journal of Pharmacognosy Published:2022


Abstract

Background and objectives: Psoriasis is a prevalent, chronic, and inflammatory disorder with good response rates using novel treatment strategies. However, side effects are a limiting factor in long-time treatment. Recent studies have demonstrated that many natural remedies have fewer side effects and are thus safer options. The aim of this study was to evaluate the efficacy of a novel topical herbal preparation in patients with plaque psoriasis. Methods: This randomized, triple-blind, vehicle-controlled, two-arm parallel trial was conducted in patients with mild-to-moderate plaque psoriasis (psoriasis area & severity index= PASI score< 12). We randomized 108 patients in 1:1 ratio to receive Boswellia-based cream (containing Boswellia spp. ethanolic extract, Boswellia spp. oil, Glycyrrhiza glabra extract, Cucurbita pepo pulp oil) or vehicle cream, both applied as a thin layer on skin lesions twice daily for four weeks. Results: Compared with vehicle, the Boswellia-based cream group showed greater reduction in mean PASI score from baseline to week two and from week two to week four (both p<0.001). After two weeks of therapy, Dermatology Life Quality Index decreased in both groups, but to a greater extent in the intervention group compared with vehicle (p=0.004). From week two to week four, this item showed an additional decrease in Boswellia-based group compared to vehicle (p=0.001). After four weeks of therapy, patients in the Boswellia-based group were more satisfied than patients in vehicle group (median score: 8 in Boswellia-based group and 5 in vehicle, p<0.001). Conclusions: The outcomes showed significant alleviation of psoriasis signs and symptoms with this herbal cream. © 2022. Open access.
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