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Magnetoelectric Nanocomposite Scaffold for High Yield Differentiation of Mesenchymal Stem Cells to Neural-Like Cells Publisher Pubmed



Esmaeili E1, 2 ; Soleimani M2 ; Ghiass MA3 ; Hatamie S1 ; Vakilian S1 ; Zomorrod MS1 ; Sadeghzadeh N1 ; Vossoughi M4, 5 ; Hosseinzadeh S6
Authors
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Authors Affiliations
  1. 1. Stem Cell Technology Research Center, Tehran, Iran
  2. 2. Department of Hematology and Cell Therapy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Department of Tissue Engineering, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  4. 4. Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Tehran, Iran
  5. 5. Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran
  6. 6. Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Cellular Physiology Published:2019


Abstract

While the differentiation factors have been widely used to differentiate mesenchymal stem cells (MSCs) into various cell types, they can cause harm at the same time. Therefore, it is beneficial to propose methods to differentiate MSCs without factors. Herein, magnetoelectric (ME) nanofibers were synthesized as the scaffold for the growth of MSCs and their differentiation into neural cells without factors. This nanocomposite takes the advantage of the synergies of the magnetostrictive filler, CoFe 2 O 4 nanoparticles (CFO), and piezoelectric polymer, polyvinylidene difluoride (PVDF). Graphene oxide nanosheets were decorated with CFO nanoparticles for a proper dispersion in the polymer through a hydrothermal process. After that, the piezoelectric PVDF polymer, which contained the magnetic nanoparticles, underwent the electrospun process to form ME nanofibers, the ME property of which has the potential to be used in areas such as tissue engineering, biosensors, and actuators. © 2019 Wiley Periodicals, Inc.
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