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The Effects of Chlorella Supplementation on Glycemic Control, Lipid Profile and Anthropometric Measures on Patients With Type 2 Diabetes Mellitus Publisher Pubmed



Hosseini AM1 ; Keshavarz SA2 ; Nasliesfahani E3 ; Amiri F4 ; Janani L5
Authors
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Authors Affiliations
  1. 1. Faculty of Medical Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  4. 4. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran

Source: European Journal of Nutrition Published:2021


Abstract

Background: Diabetes is a chronic disease and the prevalence of it is rapidly increasing. Recently, the use of natural products in chronic diseases such as diabetes has gained more attention. Chlorella, a single-celled green alga, is one of them. There have been some studies on the effects of chlorella supplementation in chronic diseases such as NAFLD, prediabetes, and diabetic mice, but none of them examined the effects of chlorella in patients with T2DM. The present study was designed to evaluate the effects of chlorella supplementation on glycemic control, lipid profile, and anthropometric indices in type 2 diabetic patients. Methods: This study is a double-blind, randomized controlled trial. 84 patients with T2DM assigned into two groups, receiving 1500 mg/day C. vulgaris or placebo for 8 weeks. Anthropometric information, blood pressure, 24-h food intake recall, and blood samples were collected at the beginning and end of the study to determine the changes of FBS, HbA1c, insulin concentration, insulin resistance, and lipid profile. Results: None of the variables investigated in this study showed a significant change after 8 weeks of intervention with C. vulgaris. Conclusion: According to the findings of this study, supplementation with C. vulgaris with a dosage of 1500 mg/day for 8 weeks, does not improve the anthropometric measurements, glycemic status, and lipid profile as well. Thus, it cannot be considered as a complementary therapeutic approach to common medications at this dosage and duration. However, future studies with a higher dosage of C. vulgaris and more prolonged than 8 weeks are needed to be done. © 2021, Springer-Verlag GmbH, DE part of Springer Nature.
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