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Does Supplementation With Royal Jelly Improve Oxidative Stress and Insulin Resistance in Type 2 Diabetic Patients?



Shidfar F1 ; Jazayeri S1 ; Mousavi SN2 ; Malek M3 ; Hosseini AF4 ; Khoshpey B1
Authors
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Authors Affiliations
  1. 1. Dept. of Nutrition, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Dept. of Cellular and Molecular Nutrition, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Research Center for Endocrinology and Metabolism, Institute of Endocrinology in Firouzgar Hospital, Iran University of Medical Sciences, Iran
  4. 4. Dept. of Statistics, School of Health Management and Information Sciences, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Public Health Published:2015

Abstract

Background: Animal studies have shown antioxidant effects of Royal Jelly (RJ) and its effect on insulin resistance as the most common complication of Type 2 diabetes. This study was conducted to determine the effect of RJ intake on serum total antioxidant capacity, Malondialdehyde and insulin resistance in T2DM. Methods: In this randomized controlled trial, forty-six type 2 diabetic patients, aged 25-65 years, with BMI of 20-30 kg/m2, and HbA1c of 6-8% were included. The patients were randomly assigned to receive 1000 mg of RJ supplement or placebo, 3 times daily for 8 weeks. HOMA-IR, anthropometric measurements, fasting blood glucose, serum insulin, total antioxidant capacity and malondialdehyde level were measured. Results: In comparison with placebo, HOMA-IR decreased (P=0.015) while serum total antioxidant capacity increased significantly in RJ group (P=0.016). No significant difference was detected for serum insulin and MDA in two groups. Conclusions: RJ intake may have favorable effects on serum TAC and HOMA-IR in diabetic patients. © 2015, Iranian Journal of Public Health. All rights reserved.
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