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Gingival Leiomyosarcoma in a Young Woman: Report of a Challenging Case Publisher



Rohani B1 ; Mahdavi N2 ; Karimi A3 ; Najafi S4, 5 ; Amiri M6
Authors
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Authors Affiliations
  1. 1. Department of Oral Medicine, School of Dentistry, Aja University of Medical Sciences, Tehran, Iran
  2. 2. Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Oral and Maxillofacial Surgery, Craniomaxillofacial Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Oral and Maxillofacial Disease, Dental Research Center, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Oral and Maxillofacial Disease, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

Source: Middle East Journal of Cancer Published:2022


Abstract

Leiomyosarcoma (LMS) is an uncommon malignant mesenchymal tumor. This tumor arises from smooth muscle cells and mostly occurs behind the peritoneum area, including pelvis and uterus. Oral LMS is exceedingly rare and occurs mainly in the bones and the soft tissues. It generally involves adults, without any considerable specific age or sex predominance. This tumor has a clinically aggressive growth pattern and is usually presented as a non-ulcerated, painless, destructive mass with a relatively firm consistency. LMS can be easily mistaken for other more common spindle cell lesions by only light microscopic evaluation; consequently, immunohis-tochemical study is helpful for the definitive diagnosis. The suggested treatment modalities include excision, radical surgery, radiation therapy, chemotherapy. Wide surgical resection is the most preferred treatment protocol. Herein, we report a clinically controversial case of gingival LMS in a 32-year-old female and also discuss the diagnostic procedures and treatment modalities in this malignancy. © 2022, Shriaz University of Medical Sciences. All rights reserved.