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Antimicrobial Action of Mesoporous Silica Nanoparticles Loaded With Cefepime and Meropenem Separately Against Multidrug-Resistant (Mdr) Acinetobacter Baumannii Publisher



Najafi A1 ; Khosravian P2 ; Validi M1 ; Porgham Daryasari M3 ; Drees F4 ; Gholipour A1
Authors
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Authors Affiliations
  1. 1. Department of Microbiology and Immunology, Cellular and Molecular Research Center, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IR, Iran
  2. 2. Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
  3. 3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biostatistics and Epidemiology, Shahrekord University of Medical Sciences, Shahrekord, Iran

Source: Journal of Drug Delivery Science and Technology Published:2021


Abstract

The extensive use of antibiotics drives the evolution of drug resistance in pathogenic bacteria clearly. Multidrug-resistance (MDR) is being a major challenge in world public health and A. baumannii is becoming an increasingly important human pathogen due to the emergence of MDR strains. In this study, amine-functionalized mesoporous silica nanoparticles (MSN-NH2) was synthesized and loaded by cefepime (CEF) and meropenem (MEP) as antibiotic drugs. The results showed a high loading efficiency of the CEF and MEP into MSN-NH2 (MSN–NH2–CEF and MSN–NH2–MEP). The prepared nanoparticles were fully characterized by Scanning Electron Microscopy (SEM), nitrogen adsorption/desorption isotherms, Fourier Transform Infrared (FT-IR) spectroscopy, and X-ray Diffraction (XRD) spectroscopy. In order to determine the antibacterial action of MSN–NH2–CEF and MSN–NH2–MEP against MDR A. baumannii, the broth microdilution and well diffusion method were used. The antimicrobial test results against MDR A. baumannii isolate were showed that drug-loaded MSN-NH2 more effective than the free drug. The results of the present study demonstrated that MSN–NH2–CEF and MSN–NH2–MEP potentiate antimicrobial activity than free drugs and enhanced the possibility of combat against A. baumannii isolate. © 2021 Elsevier B.V.
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