Poly-L-Lactic Acid Scaffold Incorporated Chitosan-Coated Mesoporous Silica Nanoparticles As Ph-Sensitive Composite for Enhanced Osteogenic Differentiation of Human Adipose Tissue Stem Cells by Dexamethasone Delivery

Poly-L-Lactic Acid Scaffold Incorporated Chitosan-Coated Mesoporous Silica Nanoparticles As Ph-Sensitive Composite for Enhanced Osteogenic Differentiation of Human Adipose Tissue Stem Cells by Dexamethasone Delivery Publisher Pubmed

Porgham Daryasari M^{1, 2} ; Dusti Telgerd M¹ ; Hossein Karami M³ ; Zandikarimi A³ ; Akbarijavar H⁴ ; Khoobi M^{2, 5} ; Seyedjafari E³ ; Birhanu G^{6, 7} ; Khosravian P⁸ ; Sadatmahdavi F⁹

Show Affiliations

1. Department of Pharmaceutical Biomaterials, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Biomaterials Group, the Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
3. Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran
4. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center (MBRC), Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, International campus (TUMS-IC), Tehran, Iran
7. School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
8. Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
9. Department of Animal and Poultry Science, College of Aburaihan, University of Tehran, Tehran, Pakdasht, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2019

Abstract

Nowadays, the development of drug-loaded electrospun organic-inorganic composite scaffolds for tissue engineering application is an attractive approach. In this study, a composite scaffold of Poly-l-lactic acid (PLLA) incorporated dexamethasone (Dexa) loaded Mesoporous Silica Nanoparticles (MSN) coated with Chitosan (CS) were fabricated by electrospinning for bone tissue engineering application. The MSN was prepared by precipitation method. After that, Dexamethasone (Dexa) was loaded into MSNs (MSN-Dexa). In the following, CS was coated over the prepared nanoparticles to form MSN-Dexa@CS and then, were mixed to PLLA solution to form MSN-Dexa@CS/PLLA composite for electrospinning. The surface morphology, hydrophilicity, tensile strength and the bioactivity of the scaffolds were characterized. The osteogenic proliferation and differentiation potential were evaluated by MTT assay and by measuring the basic osteogenic markers: the activity of the enzyme alkaline phosphatase and the level of calcium deposition. The composite scaffolds prepared here have conductive surface property and have a better osteogenic potential than pure PLLA scaffolds. Hence, the controlled release of nanoparticle containing Dexa from composite scaffold supported the osteogenesis and made the composite scaffolds ideal candidates for bone tissue engineering application and pH-sensitive delivery of drugs at the site of implantation in tissue regeneration. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Porgham Daryasari M, et al.. "Poly-L-Lactic Acid Scaffold Incorporated Chitosan-Coated Mesoporous Silica Nanoparticles As Ph-Sensitive Composite for Enhanced Osteogenic Differentiation of Human Adipose Tissue Stem Cells by Dexamethasone Delivery." Artificial Cells# Nanomedicine and Biotechnology, vol. 47, no. 1, 2019, pp. 4020-4029.
APA	Porgham Daryasari M, Dusti Telgerd M, Hossein Karami M, Zandikarimi A, Akbarijavar H, Khoobi M, Seyedjafari E, Birhanu G, Khosravian P, Sadatmahdavi F (2019). Poly-L-Lactic Acid Scaffold Incorporated Chitosan-Coated Mesoporous Silica Nanoparticles As Ph-Sensitive Composite for Enhanced Osteogenic Differentiation of Human Adipose Tissue Stem Cells by Dexamethasone Delivery. Artificial Cells# Nanomedicine and Biotechnology, 47(1), 4020-4029.
Chicago	Porgham Daryasari M, Dusti Telgerd M, Hossein Karami M, Zandikarimi A, Akbarijavar H, Khoobi M, Seyedjafari E, Birhanu G, Khosravian P, Sadatmahdavi F. "Poly-L-Lactic Acid Scaffold Incorporated Chitosan-Coated Mesoporous Silica Nanoparticles As Ph-Sensitive Composite for Enhanced Osteogenic Differentiation of Human Adipose Tissue Stem Cells by Dexamethasone Delivery." Artificial Cells# Nanomedicine and Biotechnology 47, no. 1 (2019): 4020-4029.
Harvard	Porgham Daryasari M et al. (2019) 'Poly-L-Lactic Acid Scaffold Incorporated Chitosan-Coated Mesoporous Silica Nanoparticles As Ph-Sensitive Composite for Enhanced Osteogenic Differentiation of Human Adipose Tissue Stem Cells by Dexamethasone Delivery', Artificial Cells# Nanomedicine and Biotechnology, 47(1), pp. 4020-4029.
Vancouver	Porgham Daryasari M, Dusti Telgerd M, Hossein Karami M, Zandikarimi A, Akbarijavar H, Khoobi M, et al.. Poly-L-Lactic Acid Scaffold Incorporated Chitosan-Coated Mesoporous Silica Nanoparticles As Ph-Sensitive Composite for Enhanced Osteogenic Differentiation of Human Adipose Tissue Stem Cells by Dexamethasone Delivery. Artificial Cells# Nanomedicine and Biotechnology. 2019;47(1):4020-4029.
BibTex	@article{ author = {Porgham Daryasari M and Dusti Telgerd M and Hossein Karami M and Zandikarimi A and Akbarijavar H and Khoobi M and Seyedjafari E and Birhanu G and Khosravian P and Sadatmahdavi F}, title = {Poly-L-Lactic Acid Scaffold Incorporated Chitosan-Coated Mesoporous Silica Nanoparticles As Ph-Sensitive Composite for Enhanced Osteogenic Differentiation of Human Adipose Tissue Stem Cells by Dexamethasone Delivery}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {47}, number = {1}, pages = {4020-4029}, year = {2019} }
RIS	TY - JOUR AU - Porgham Daryasari M AU - Dusti Telgerd M AU - Hossein Karami M AU - Zandikarimi A AU - Akbarijavar H AU - Khoobi M AU - Seyedjafari E AU - Birhanu G AU - Khosravian P AU - Sadatmahdavi F TI - Poly-L-Lactic Acid Scaffold Incorporated Chitosan-Coated Mesoporous Silica Nanoparticles As Ph-Sensitive Composite for Enhanced Osteogenic Differentiation of Human Adipose Tissue Stem Cells by Dexamethasone Delivery JO - Artificial Cells# Nanomedicine and Biotechnology VL - 47 IS - 1 SP - 4020 EP - 4029 PY - 2019 ER -

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