The Effect of Cinnamon Supplementation on Cardiovascular Risk Factors in Adults: A Grade Assessed Systematic Review, Dose–Response and Meta-Analysis of Randomized Controlled Trials Publisher Pubmed



A Jafari ALI ; H Mardani HELIA ; Ah Faghfouri Amir HOSSEIN ; M Ahmadianmoghaddam MINOO ; V Musazadeh VALI ; A Alaghi ALIREZA
Source: Journal of Health, Population and Nutrition Published:2025

Abstract

Background: Numerous clinical studies have suggested that cinnamon supplementation may be effective for cardiovascular disease risk factors, but the findings are controversial. This comprehensive systematic review and meta-analysis aimed to assess the impact of cinnamon supplementation on cardiovascular disease risk factors. Methods: Relevant studies were identified through electronic searches of databases, including Web of Science, PubMed, Central, Scopus, and Embase, up to July 2024. Results: Forty-nine studies were included. Cinnamon supplementation significantly reduced WC (SMD = − 0.40; 95% (CI): − 0.73, − 0.06), DBP (SMD = − 1.04; 95% CI: − 1.54, − 0.55), SBP (SMD = − 0.85; 95% CI: − 1.54, − 0.16), fasting glucose (SMD = − 1.28; 95% CI: − 1.65, − 0.90), fasting insulin (SMD = − 0.26; 95% CI: − 0.50, − 0.02), HbA1c (SMD = − 0.71; 95% CI: − 1.02, − 0.40), HOMA-IR (SMD = − 0.54; 95% CI: − 0.82, − 0.26), postprandial blood glucose (SMD = − 2.28; 95% CI: − 3.48, − 1.08), CRP (SMD = − 0.78; 95% CI: − 1.28, − 0.27), LDL-C (SMD = − 0.71; 95% CI: − 1.02, − 0.40), total cholesterol (TC) (SMD = − 1.15; 95% CI: − 1.55, − 0.75), triglycerides (TG) (SMD = − 0.91; 95% CI: − 1.25, − 0.56), and MDA (SMD = − 0.76; 95% CI: − 1.07, − 0.45). Additionally, cinnamon supplementation significantly elevated HDL-C levels (SMD = 0.56; 95% CI: 0.23, 0.89). Conclusion: Cinnamon supplementation demonstrated significant benefits in improving cardiovascular risk factors. These findings suggest its potential as an adjunct therapy for improving cardiovascular disease risk factors. © 2025 Elsevier B.V., All rights reserved.