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The Effects of Green Coffee Extract Supplementation on Glycemic Indices and Lipid Profile in Adults: A Systematic Review and Dose-Response Meta-Analysis of Clinical Trials Publisher Pubmed



Asbaghi O1 ; Sadeghian M2 ; Nasiri M3, 4 ; Khodadost M5, 6 ; Shokri A7 ; Panahande B8 ; Pirouzi A9 ; Sadeghi O10, 11
Authors
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Authors Affiliations
  1. 1. Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
  2. 2. Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Department of Operating Room Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  8. 8. Department of Nutrition, School of Health, Yasuj University of Medical Sciences, Yasuj, Iran
  9. 9. Gerash University of Medical Sciences, Gerash, Iran
  10. 10. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Nutrition Journal Published:2020


Abstract

Background: The role of coffee consumption in the risk of cardiovascular diseases has been debated for many years. The current study aimed to summarize earlier evidence on the effects of green coffee extract (GCE) supplementation on glycemic indices and lipid profile. Methods: We searched available online databases for relevant clinical trials published up to October 2019. All clinical trials investigating the effect of GCE supplementation, compared with a control group, on fasting blood glucose (FBG), serum insulin, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were included. Overall, 14 clinical trials with a total sample size of 766 participants were included in the current meta-analysis. Results: We found a significant reducing effect of GCE supplementation on FBG (weighted mean difference (WMD): -2.35, 95% CI: - 3.78, - 0.92 mg/dL, P = 0.001) and serum insulin (WMD: -0.63, 95% CI: - 1.11, - 0.15 μU/L, P = 0.01). With regard to lipid profile, we observed a significant reduction only in serum levels of TC following GCE supplementation in the overall meta-analysis (WMD: -4.51, 95% CI: - 8.39, - 0.64, P = 0.02). However, subgroup analysis showed a significant reduction in serum TG in studies enrolled both genders. Also, such a significant reduction was seen in serum levels of LDL and HDL when the analyses confined to studies with intervention duration of ≥8 weeks and those included female subjects. In the non-linear dose-response analyses, we found that the effects of chlorogenic acid (CGA) dosage, the main polyphenol in GCE, on FBG, TG and HDL were in the non-linear fashions. Conclusion: In conclusion, we found that GCE supplementation improved FBG and serum levels of insulin and TC. Also, there was a significant improvement in other markers of lipid profile in some subgroups of clinical trials. © 2020 The Author(s).
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