Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
A Mesoporous Magnetic Fe3o4/Biomof-13 With a Core/Shell Nanostructure for Targeted Delivery of Doxorubicin to Breast Cancer Cells Publisher



Taheriledari R1 ; Zareishokat S1 ; Qazi FS1 ; Ghaforigorab M1 ; Ganjali F1 ; Kashtiaray A1 ; Mahdavi M2 ; Safavi M3 ; Maleki A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
  2. 2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, 14166-34793, Iran
  3. 3. Department of Biotechnology, Iranian Research Organization for Science and Technology (IROST), Tehran, 33531-36846, Iran

Source: ACS Applied Materials and Interfaces Published:2023


Abstract

In the current project, magnetic Bio-MOF-13 was used as an efficient carrier for the targeted delivery and controlled release of doxorubicin (DOX) to MDA-MB-231 cells. Magnetic Bio-MOF-13 was prepared by two strategies and compared to determine the optimal state of the structure. In the first path, Bio-MOF-13 was grown in situ on the surface of Fe3O4 nanoparticles (core/shell structure), while in the second method, the two presynthesized materials were mixed together (surface composite). Core/shell structure, among prepared nanocomposites, was chosen for biological evaluation due to its favorable structural features like a high accessible surface area and pore volume. Also, it is highly advantageous for drug release due to its ability to selectively release DOX in the acidic pH of breast cancer cells, while preventing any premature release in the neutral pH of the blood. Drug release from the carrier structure is precisely controlled not only by pH but also by an external magnetic field, guaranteeing accurate drug delivery at the intended location. Confocal microscopy and flow cytometry assay clearly confirms the increase in drug concentration in the MDA-MB-231 cell line after external magnet applying. This point, along with the low toxicity of the carrier components, makes it a suitable candidate for injectable medicine. According to MTT results, the percentage of viable MDA-MB-231 cells after treatment with 10 μL of DOX@Fe3O4/Bio-MOF-13 core/shell composite in different concentrations, in the presence and absence of magnetic field is 0.87 ± 0.25 and 2.07 ± 0.15, respectively. As a result, the DOX@Fe3O4/Bio-MOF-13 core/shell composite was performed and approved for targeted drug delivery and magnetic field-assisted controlled release of DOX to the MDA-MB-231 cell line. © 2023 American Chemical Society.
Related Docs
1. A Mesoporous Magnetic Fe3o4/Biomof-13 With a Core/Shell Nanostructure for Targeted Delivery of Doxorubicin to Breast Cancer Cells, ACS Applied Materials and Interfaces (2025)
2. Synthesis of Green Benzamide-Decorated Uio-66-Nh2 for Biomedical Applications, Chemosphere (2022)
3. Evolution in Mof Porosity, Modularity, and Topology, Engineering Materials (2023)
4. Preparation of Uio-66 Loaded Letrozole Nano-Drug Delivery System: Enhanced Anticancer and Apoptosis Activity, AMB Express (2024)
Experts (# of related papers)
Ronak Bakhtiari (1)
Mohammad Mahdavi (1)