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Synthesis of Green Benzamide-Decorated Uio-66-Nh2 for Biomedical Applications Publisher Pubmed



Rabiee N1, 2 ; Ghadiri AM3 ; Alinezhad V3 ; Sedaghat A4 ; Ahmadi S5, 6 ; Fatahi Y7, 8 ; Makvandi P9 ; Saeb MR10 ; Bagherzadeh M3 ; Asadnia M2 ; Varma RS11 ; Lima EC12
Authors
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Authors Affiliations
  1. 1. Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran, Iran
  2. 2. School of Engineering, Macquarie University, Sydney, 2109, NSW, Australia
  3. 3. Department of Chemistry, Sharif University of Technology, Tehran, Iran
  4. 4. Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran
  8. 8. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran
  9. 9. Istituto Italiano di Tecnologia, Centre for Materials Interfaces, Viale Rinaldo Piaggio 34, Pontedera, Pisa, 56025, Italy
  10. 10. Department of Polymer Technology, Faculty of Chemistry, Gdansk University of Technology, G. Narutowicza 11/12 80-233, Gdansk, Poland
  11. 11. Regional Center of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University, Slechtitelu 27, Olomouc, 783 71, Czech Republic
  12. 12. Institute of Chemistry, Federal University of Rio Grande Do Sul (UFRGS), Av. Bento Goncalves 9500, Postal Box, 15003, ZIP, 91501-970, Brazil

Source: Chemosphere Published:2022


Abstract

Metal-organic frameworks (MOFs) biocompatible systems can host enzymes/bacteria/viruses. Herein we synthesized a series of fatty acid amide hydrolase (FAAH)-decorated UiO-66-NH2 based on Citrus tangerine leaf extract for drug delivery and biosensor applications. Five chemically manipulated FAAH-like benzamides were localized on the UiO-66-NH2 surface with physical interactions. Comprehensive cellular and molecular analyses were conducted on HEK-293, HeLa, HepG2, PC12, MCF-7, and HT-29 cell lines (cytotoxicity assessment after 24 and 48 h). MTT results proved above 95 and 50% relative cell viability in the absence and presence of the drug, respectively. A complete targeted drug-releasing capability of nanocarriers was demonstrated after capping with leaf extract from Citrus tangerine, with a stimuli-responsive effect in acidic media. Targeted delivery was complete to the nucleus and cytoplasm of HT-29 cell, but merely to the cytoplasm of HeLa cell lines. Nanocarrier could be targeted for drug delivery to the cytoplasm of the HeLa cell line and to both the nucleus and cytoplasm of HT-29 cell lines. MOF-based nanocarriers proved authentic in vivo towards kidney and liver tissues with targeted cancerous cells efficiently. Besides, FAAH-like molecules revealed optical biosensor potential with high selectivity (even ˂5 nM LOD) towards ssDNA, sgRNA, and Anti-cas9 proteins. © 2022 Elsevier Ltd
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