Unveiling the Potential Role of Micro/Nano Biomaterials in the Treatment of Helicobacter Pylori Infection Publisher Pubmed



M Fathi Kisomi MISAGH ; A Yadegar ABBAS ; T Shekari TARA ; M Amin MOHSEN ; A Llopislorente ANTONI ; C Liu CHENGUANG ; I Haririan ISMAEL ; Ha Aghdaei Hamid ASADZADEH ; Ma Shokrgozar Mohammad ALI ; Mr Zali Mohammad REZA
Source: Expert Review of Anti-Infective Therapy Published:2024

Abstract

Introduction: Helicobacter pylori causes stubborn infections and leads to a variety of stomach disorders, such as peptic ulcer, chronic atrophic gastritis, and gastric cancer. Although antibiotic-based approaches have been widely used against H. pylori, some challenges such as antibiotic resistance are increasing in severity. Therefore, simpler but more effective strategies are needed. Areas Covered: In this review, basic information on functionalized and non-functionalized micro/nano biomaterials and routes of administration for H. pylori inhibition are provided in an easy-to-understand format. Afterward, in vitro and in vivo studies of some promising bio-platforms including metal-based biomaterials, biopolymers, small-molecule saccharides, and vaccines for H. pylori inhibition are discussed in a holistic manner. Expert Opinion: Functionalized or non-functionalized micro/nano biomaterials loaded with anti-H. pylori agents can show efficient bactericidal activity with no/slight negative influence on the host gastrointestinal microbiota. However, this claim needs to be substantiated with hard data such as assessment of the biopharmaceutical parameters of anti-H. pylori systems and the measurement of diversity/abundance of bacterial genera in the host gastric/gut microbiota before and after H. pylori eradication. © 2024 Elsevier B.V., All rights reserved.