Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Quantitation of Cd4+/Cd25+/High/Cd127low/- Regulatory T-Cells in Rheumatoid Arthritis Patients Publisher Pubmed



Delavari S1, 2, 3 ; Ghafourian M2, 4 ; Rajaei E5 ; Mowla K5 ; Ghadiri A1, 2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Department of Internal Medicine, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Iranian Journal of Immunology Published:2021


Abstract

Background: Rheumatoid arthritis (RA) is the most common rheumatoid disease of unknown etiology, determined by the articular cartilage destruction and bone loss. The hallmark of RA is the defect in immune tolerance. Regulatory T cells (Treg) play a critical role in the protection of peripheral tolerance. Objective: To assess the percentage of CD4+/CD25+/high/ CD127low/- Treg cells in peripheral blood of RA patients as compared with the healthy individuals. Methods: The number of CD4+/CD25+/high/CD127low/- Treg cells was assessed by multicolor flow cytometry. The clinical disease activity of RA patients was determined by disease activity score 28 (DAS-28). The correlations of DAS-28 and erythrocyte sedimentation rate (ESR) with Treg cells were evaluated. Results: The percentage of CD4+/CD25+/high/CD127low/- Treg cells in peripheral blood of RA patients significantly decreased as compared with the healthy individuals (P= 0.0002). The percentage of CD4+/ CD25+/high/CD127low/- Treg cells negatively correlated with DAS-28 and ESR. Conclusion: This study concludes that the defect of Treg cells plays a vital role in the pathogenesis of this disease. Further studies are necessary to determine the role of Treg cells in the clinical course of rheumatoid arthritis. © 2021, Shiraz University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. Emerging Therapeutic Potential of Regulatory T (Treg) Cells for Rheumatoid Arthritis: New Insights and Challenges, International Immunopharmacology (2022)
2. Analysis of Helios Gene Expression and Foxp3 Tsdr Methylation in the Newly Diagnosed Rheumatoid Arthritis Patients, Immunological Investigations (2018)
3. Relationship Between Vitamin D Plasma Level and Foxp3 Gene Expression Among Rheumatoid Arthritis Patients, Scientific Journal of Kurdistan University of Medical Sciences (2018)
4. Microrna Signature of Regulatory T Cells in Health and Autoimmunity, Biomedicine and Pharmacotherapy (2018)
5. Adoptive Treg Cell-Based Immunotherapy: Frontier Therapeutic Aspects in Rheumatoid Arthritis, Immunotherapy (2020)
6. Pd-1/Pd-L and Autoimmunity: A Growing Relationship, Cellular Immunology (2016)
7. Role of Rare Immune Cells in Common Variable Immunodeficiency, Pediatric Allergy and Immunology (2022)
8. The Impact of Functional Promoter Variants in Interleukin‑18 on Susceptibility to Rheumatoid Arthritis in Iranian Population, Advanced Biomedical Research (2024)
Experts (# of related papers)
View all Related Experts
Ahmad Reza Jamshidi (7)
Mahdi Mahmoudi (6)
Other Related Docs
9. A Phase Iii, Randomized, Two-Armed, Double-Blind, Parallel, Active Controlled, and Non-Inferiority Clinical Trial to Compare Efficacy and Safety of Biosimilar Adalimumab (Cinnora®) to the Reference Product (Humira®) in Patients With Active Rheumatoid Arthritis, Arthritis Research and Therapy (2017)
10. Targeting of Circulating Th17 Cells by Β-D-Mannuronic Acid (M2000) As a Novel Medication in Patients With Rheumatoid Arthritis, Inflammopharmacology (2018)
11. Artificial Intelligence in Rheumatoid Arthritis: Current Status and Future Perspectives: A State-Of-The-Art Review, Rheumatology and Therapy (2022)
12. Role of T Cells in the Pathogenesis of Rheumatoid Arthritis: Focus on Immunometabolism Dysfunctions, Inflammation (2023)
13. The Possible Role of Interleukin-35 and Its Therapeutic Potential in Pemphigus, International Immunopharmacology (2017)
14. International Multicenter Randomized, Placebo-Controlled Phase Iii Clinical Trial of Β-D-Mannuronic Acid in Rheumatoid Arthritis Patients, Inflammopharmacology (2019)
15. Nf-Κb Signaling in Rheumatoid Arthritis With Focus on Fibroblast-Like Synoviocytes, Autoimmunity Highlights (2020)
16. The Effect of Poly I:C or Lps Priming on the Therapeutic Efficacy of Mesenchymal Stem Cells in an Adjuvant-Induced Arthritis Rat Model, Pharmacological Reports (2022)
17. A Systems Biology Approach for Mirna-Mrna Expression Patterns Analysis in Rheumatoid Arthritis, Combinatorial Chemistry and High Throughput Screening (2021)
18. The Potent Inhibitory Effect of Β-D-Mannuronic Acid (M2000) As a Novel Nsaid With Immunosuppressive Property on Anti-Cyclic Citrullinated Peptide Antibodies, Rheumatoid Factor and Antidsdna Antibodies in Patients With Rheumatoid Arthritis, Current Drug Discovery Technologies (2017)
19. Altered Microrna Expression and Immunosuppressive Cytokine Production by Regulatory T Cells of Ulcerative Colitis Patients, Immunological Investigations (2016)
20. Autoimmune Diseases, Clinical Immunology (2022)
21. Identification, Isolation, and Functional Assay of Regulatory T Cells, Immunological Investigations (2016)
22. A Phase I/Ii Randomized, Controlled, Clinical Trial for Assessment of the Efficacy and Safety of Β-D-Mannuronic Acid in Rheumatoid Arthritis Patients, Inflammopharmacology (2018)
23. Mesenchymal Stem Cells Induce Expansion of Regulatory T Cells in Abortion-Prone Mice, Reproduction (2021)
24. Anti-Inflammatory Effects of Prima-1Met (Mutant P53 Reactivator) Induced by Inhibition of Nuclear Factor-Κb on Rheumatoid Arthritis Fibroblast-Like Synoviocytes, Inflammopharmacology (2023)
25. Recent Advances in Understanding the Pathogenesis of Rheumatoid Arthritis: New Treatment Strategies, Cells (2021)
26. Comparative Immune Response in Children and Adults With H. Pylori Infection, Journal of Immunology Research (2015)
27. The Role of Nk Cells in Rheumatoid Arthritis, Inflammation Research (2021)
28. The Relationship Between Porphyromonas Gingivalis and Rheumatoid Arthritis: A Cross-Sectional Clinical, Microbiological, and Molecular Approach, Journal of Kerman University of Medical Sciences (2020)