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The Effects of Elaeagnus Angustifolia L. on Lipid and Glycaemic Profiles and Cardiovascular Function in Menopausal Women: A Double-Blind, Randomized, Placebo-Controlled Study Publisher Pubmed



Shabani M1 ; Rezaei A1, 2 ; Badehnoosh B3, 4 ; Qorbani M5, 6 ; Yaseri M7 ; Ramezani R8 ; Emaminia F1
Authors
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Authors Affiliations
  1. 1. School of Biology, Damghan University, Damghan, Iran
  2. 2. Institute of Biological Sciences, Damghan University, Damghan, Iran
  3. 3. Department of Gynecology and Obstetrics, Faculty of Medical Science, Alborz University of Medical Science, Karaj, Iran
  4. 4. Dietary Supplement and Probiotic Research Center, Alborz University of Medical Science, Karaj, Iran
  5. 5. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Statistic, Faculty of Mathematics and Computer Science, Damghan University, Damghan, Iran

Source: International Journal of Clinical Practice Published:2021


Abstract

Aims: The reduced production of ovarian hormones is considered to be the cause of an increase in the incidence of heart disease in women after menopause. Phytoestrogens are found in various herbal sources and are considered as an alternative to hormone therapy because of structural similarity with oestrogen. Elaeagnus angustifolia L., known as Senjed in Persian, is used in Iranian traditional medicine with various medicinal properties, contains valuable compounds, including two types of phytoestrogens. The aim of the present study was to investigate the efficacy of E. angustifolia fruit on the cardiovascular function, lipid and glycaemic profiles in postmenopausal women. Methods: In this double-blind placebo-controlled clinical trial, 58 postmenopausal women were randomly assigned into two experimental groups of medicinal herb (15 g/day of the whole E. angustifolia fruit powder) and placebo (15 g/day of isomalt + corn starch). Before the trial and after 10 weeks of the treatment, cardiovascular function (heart rate, blood pressure), serum glycaemic profile (fasting blood glucose; glycated haemoglobin, HbA1C), insulin and lipid profile (total cholesterol, TC; triglyceride, TG; LDL-C and HDL-C) were measured. Results: Heart rate, and serum level of LDL-C and HDL-C significantly decreased after treatment with E. angustifolia. Changes in glycaemic profile were not clinically significant. In addition, some studied biochemical parameters significantly changed in the placebo group. Conclusions: E. angustifolia was somewhat effective in improving cardiovascular function and lipid profile, as well as the overall health of postmenopausal women. However, the use of isomalt and corn starch in menopausal women needs further investigation. © 2020 John Wiley & Sons Ltd
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