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The Effects of Melissa Officinalis on Echocardiography, Exercise Test, Serum Biomarkers, and Blood Pressure in Patients With Chronic Stable Angina Publisher



Javid AZ1 ; Haybar H2 ; Dehghan P3 ; Haghighizadeh MH4 ; Mohaghegh SM5 ; Ravanbakhsh M6 ; Mohammadzadeh A5 ; Bahrololumi SS7
Authors
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Authors Affiliations
  1. 1. Nutrition and Metabolic Diseases Research Center & Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Golestan hospital clinical research development unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Nutrition Research Center, Department of Food Science and Technology, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Biostatics, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Department of Nutrition sciences, School of Para-medicine, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  7. 7. Department of Nutrition, School of Nutrition, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Herbal Medicine Published:2018


Abstract

Background: Cardiovascular disease is one of the major causes of mortality from non-communicable diseases. In recent years there has been a growing interest in herbal medicine as a complementary therapy for the treatment of multiple conditions. The aim of this study was to determine the effects of Melissa officinalis (MO) on the results of echocardiography, exercise stress test, cardiovascular serum biomarkers such as lactate dehydrogenase (LDH) and nitric oxide (NO), and blood pressure in patients with chronic stable angina (CSA). Materials & methods: Eighty patients with CSA were randomly divided into case and control groups in a double-blind clinical trial. They received 3 g/d lemon balm or placebo for 2 months. Anthropometric measurements, echocardiography and exercise stress test were performed before and after intervention. Also, LDH and NO were measured as cardiovascular parameters. Results: The mean levels of Ejection Fraction (EF) in the echocardiographyand maximum workload in the exercise test were significantly higher in the intervention group compared with placebo (p < 0.01) post intervention. Moreover, the mean serum level of LDH was significantly (p < 0.001) lower in the intervention group compared with control group. Additionally, the mean serum level of NO was higher in the intervention group compared with placebo (p < 0.01) post intervention. Systolic and diastolic blood pressure (SBP, DBP) were also decreased in the intervention group compared with placebo (p < 0.05) post intervention. Conclusion: The results show that MO supplementation may improve EF,maximum workload, cardiovascular serum biomarkers (LDH, NO), and blood pressure in patients with CSA. © 2017 Elsevier GmbH
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