Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Effect of Hormone Therapy on Bone Mineral Density and Cardiovascular Factors Among Iranian Female Athletes With Amenorrhea/Oligomenorrhea: A Randomized Clinical Trial Publisher



Dadgostar H1 ; Soleimany G1 ; Movaseghi S2 ; Dadgostar E3 ; Lotfian S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Sports and Exercise Medicine, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Sports Medicine Federation of Islamic Republic of Iran, Tehran, Iran

Source: Medical Journal of the Islamic Republic of Iran Published:2018


Abstract

Background: Functional hypothalamic menstrual disorder (FHMD) has a destructive effect on the athlete's bone mineral density and cardiovascular system. Utilizing hormone replacement therapy to treat FHMD in athletes is controversial. This study was conducted to examine the effect of hormone therapy on bone density and the cardiovascular system of professional female athletes with FHMD. Methods: In this study, 18 female athletes with at least a 2- year history of FHMD were recruited in a 9-month single blind randomized clinical intervention (RCT) and randomly classified into 2 groups: the oral contraceptive pills (OCP) group, who received a lowdose combined oral contraceptive (OC) containing 30 xg ethinyl estradiol and 150 μg levonorgestrel (n= 10), and the control group (n = 8). Bone mineral densitometry (BMD) and certain cardiovascular risk factors were measured before and after the 9-month trial. The Chi square test was used to compare the quantitative and qualitative results. Results: Bone mineral density did not change significantly in either group. Very low density lipoprotein (VLDL) (p= 0.035) and Apolipoprotein B (Apo B) (p= 0.04) reduced significantly in the OCP group. An increase was observed in the serum levels of Apolipoprotein A (Apo A) (p= 0.01) in the control group. Changes in the Apo B to Apo A ratio was significant in both groups (OCP group: p= 0.018, control group: p= 0.040). No significant changes were observed in the other measured factors. Conclusion: Although the administration of estrogen did not significantly increase bone mineral density, it had positive effects on the cardiovascular system and lipid profile. © Iran University of Medical Sciences.