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Vitamin D Status and Its Relationship With Bone Mineral Density in a Healthy Iranian Population; [Correlacao Entre Os Niveis De Vitamina D E Densidade Mineral Ossea Em Uma Populacao Iraniana Saudavel] Publisher



Khashayar P1, 2 ; Aghaei Meybodi HR1 ; Rezai Hemami M3 ; Keshtkar A4, 5 ; Dimai HP6 ; Larijani B3
Authors
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Authors Affiliations
  1. 1. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Teera, Iran
  2. 2. Center for Microsystems Technology (CMST), Ghent University, Ghent, Belgium
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Teera, Iran
  4. 4. Department of Health, The Ministry of Health and Medical Education (MOHME), Teera, Iran
  5. 5. Department of Nutrition, The Ministry of Health and Medical Education (MOHME), Teera, Iran
  6. 6. Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria

Source: Revista Brasileira de Ortopedia Published:2016


Abstract

Objectives Considering the controversial results regarding the relationship between vitamin D levels and bone mineral density in different populations, the present study was designed to evaluate this correlation in a healthy Iranian population. Methods Using a random cluster sample of apparently healthy men and women, this multicenter cross‐sectional study was carried out among 4450 individuals living in urban areas of five major cities in Iran. Bone mineral density (BMD) values at different sites were analyzed along with the serum levels of 25(OH)D and PTH. Analysis of variance (Anova) was used to estimate the main effects, through comparing the mean values of these markers based on the bone mineral density status of the study group in each sex. Results 25(OH)D levels were inversely correlated with BMD values at total hip (r = −0.062 in men and r = −0.057 in women) and spine (r = −0.076 in men and r = −0.107 in women). After adjusting the data for age, the inverse correlation was no longer statistically significant. Conclusion Serum 25(OH)D levels are inversely correlated with bone mass values in both sexes. © 2015 Sociedade Brasileira de Ortopedia e Traumatologia