Contribution of Long Noncoding Rna Hotair Variants to Preeclampsia Susceptibility in Iranian Women

Contribution of Long Noncoding Rna Hotair Variants to Preeclampsia Susceptibility in Iranian Women Publisher Pubmed

Esmkhani S¹ ; Sadeghi H² ; Ghasemian M³ ; Pirjani R⁴ ; Aminbeidokhti M⁵ ; Gholami M⁶ ; Yassaee F⁷ ; Mirfakhraie R⁵

Show Affiliations

1. Menâ€™s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Obstetrics and Gynecology Department, Arash Women Hospital, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Department of Biochemistry and Genetics, School of Medicine, Arak University of Medical Sciences, Arak, Iran
7. Department of Obstetrics and Gynecology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Hypertension in Pregnancy Published:2021

Abstract

Objective: To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method: The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. Results: HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30–7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51–13.42, P < 0.0001; respectively). Conclusion: This study confirmed the association of HOTAIR rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Esmkhani S, et al.. "Contribution of Long Noncoding Rna Hotair Variants to Preeclampsia Susceptibility in Iranian Women." Hypertension in Pregnancy, vol. 40, no. 1, 2021, pp. 29-35.
APA	Esmkhani S, Sadeghi H, Ghasemian M, Pirjani R, Aminbeidokhti M, Gholami M, Yassaee F, Mirfakhraie R (2021). Contribution of Long Noncoding Rna Hotair Variants to Preeclampsia Susceptibility in Iranian Women. Hypertension in Pregnancy, 40(1), 29-35.
Chicago	Esmkhani S, Sadeghi H, Ghasemian M, Pirjani R, Aminbeidokhti M, Gholami M, Yassaee F, Mirfakhraie R. "Contribution of Long Noncoding Rna Hotair Variants to Preeclampsia Susceptibility in Iranian Women." Hypertension in Pregnancy 40, no. 1 (2021): 29-35.
Harvard	Esmkhani S et al. (2021) 'Contribution of Long Noncoding Rna Hotair Variants to Preeclampsia Susceptibility in Iranian Women', Hypertension in Pregnancy, 40(1), pp. 29-35.
Vancouver	Esmkhani S, Sadeghi H, Ghasemian M, Pirjani R, Aminbeidokhti M, Gholami M, et al.. Contribution of Long Noncoding Rna Hotair Variants to Preeclampsia Susceptibility in Iranian Women. Hypertension in Pregnancy. 2021;40(1):29-35.
BibTex	@article{ author = {Esmkhani S and Sadeghi H and Ghasemian M and Pirjani R and Aminbeidokhti M and Gholami M and Yassaee F and Mirfakhraie R}, title = {Contribution of Long Noncoding Rna Hotair Variants to Preeclampsia Susceptibility in Iranian Women}, journal = {Hypertension in Pregnancy}, volume = {40}, number = {1}, pages = {29-35}, year = {2021} }
RIS	TY - JOUR AU - Esmkhani S AU - Sadeghi H AU - Ghasemian M AU - Pirjani R AU - Aminbeidokhti M AU - Gholami M AU - Yassaee F AU - Mirfakhraie R TI - Contribution of Long Noncoding Rna Hotair Variants to Preeclampsia Susceptibility in Iranian Women JO - Hypertension in Pregnancy VL - 40 IS - 1 SP - 29 EP - 35 PY - 2021 ER -

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