An Intron Variant in the Flt1 Gene Increases the Risk of Preeclampsia in Iranian Women

An Intron Variant in the Flt1 Gene Increases the Risk of Preeclampsia in Iranian Women Publisher Pubmed

Aminbeidokhti M¹ ; Gholami M² ; Abedindo A¹ ; Pirjani R³ ; Sadeghi H¹ ; Karamoddin F⁴ ; Yassaee VR⁵ ; Mirfakhraie R¹

Show Affiliations

1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2. Department of Biochemistry and Genetics, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
3. Obstetrics and Gynecology Department, Arash Women Hospital, Tehran University of Medical Sciences, Tehran, Iran
4. Obstetrics and Gynecology Department, Shafa Hospital, Semnan, Iran
5. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Clinical and Experimental Hypertension Published:2019

Abstract

Background: Preeclampsia is a hypertensive disorder that affects pregnancy, mother, and fetus. Pathogenesis of preeclampsia could be associated with the angiogenesis pathways. The vascular endothelial growth factor (VEGF) family is one of the important factors for normal pregnancy and angiogenesis. Genetic variations in the gene family members may play a role in the etiology of preeclampsia. We investigated the possible association between VEGFA gene rs3025039, and VEGFR1 (FLT1) gene rs722503 polymorphisms and preeclampsia in a sample of Iranian patients. Methods: Genotyping was performed in 395 women, including, 204 pre-eclamptic pregnant women and 191 healthy normotensive pregnant women by using the PCR-RFLP method. Results: The rs722503 polymorphism was associated with preeclampsia under the dominant model (P = 0.04, OR = 1.53, 95% CI: 1.03–2.27). No significant difference was observed for the rs3025039 alleles and genotypes in the studied groups. Conclusions: Based on our study, rs722503 polymorphism in the FLT1 gene may play an important role in susceptibility to preeclampsia. © 2018, © 2018 Taylor & Francis.

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Experts (# of related papers)

Reihaneh Pirjani (1)

Style	Citing Format
MLA	Aminbeidokhti M, et al.. "An Intron Variant in the Flt1 Gene Increases the Risk of Preeclampsia in Iranian Women." Clinical and Experimental Hypertension, vol. 41, no. 8, 2019, pp. 697-701.
APA	Aminbeidokhti M, Gholami M, Abedindo A, Pirjani R, Sadeghi H, Karamoddin F, Yassaee VR, Mirfakhraie R (2019). An Intron Variant in the Flt1 Gene Increases the Risk of Preeclampsia in Iranian Women. Clinical and Experimental Hypertension, 41(8), 697-701.
Chicago	Aminbeidokhti M, Gholami M, Abedindo A, Pirjani R, Sadeghi H, Karamoddin F, Yassaee VR, Mirfakhraie R. "An Intron Variant in the Flt1 Gene Increases the Risk of Preeclampsia in Iranian Women." Clinical and Experimental Hypertension 41, no. 8 (2019): 697-701.
Harvard	Aminbeidokhti M et al. (2019) 'An Intron Variant in the Flt1 Gene Increases the Risk of Preeclampsia in Iranian Women', Clinical and Experimental Hypertension, 41(8), pp. 697-701.
Vancouver	Aminbeidokhti M, Gholami M, Abedindo A, Pirjani R, Sadeghi H, Karamoddin F, et al.. An Intron Variant in the Flt1 Gene Increases the Risk of Preeclampsia in Iranian Women. Clinical and Experimental Hypertension. 2019;41(8):697-701.
BibTex	@article{ author = {Aminbeidokhti M and Gholami M and Abedindo A and Pirjani R and Sadeghi H and Karamoddin F and Yassaee VR and Mirfakhraie R}, title = {An Intron Variant in the Flt1 Gene Increases the Risk of Preeclampsia in Iranian Women}, journal = {Clinical and Experimental Hypertension}, volume = {41}, number = {8}, pages = {697-701}, year = {2019} }
RIS	TY - JOUR AU - Aminbeidokhti M AU - Gholami M AU - Abedindo A AU - Pirjani R AU - Sadeghi H AU - Karamoddin F AU - Yassaee VR AU - Mirfakhraie R TI - An Intron Variant in the Flt1 Gene Increases the Risk of Preeclampsia in Iranian Women JO - Clinical and Experimental Hypertension VL - 41 IS - 8 SP - 697 EP - 701 PY - 2019 ER -

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