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Graphene Oxide Incorporated Polycaprolactone/Chitosan/Collagen Electrospun Scaffold: Enhanced Osteogenic Properties for Bone Tissue Engineering Publisher Pubmed



Aidun A1, 2 ; Safaei Firoozabady A3 ; Moharrami M2, 4 ; Ahmadi A5 ; Haghighipour N1 ; Bonakdar S1 ; Faghihi S6
Authors
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Authors Affiliations
  1. 1. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Tissues and Biomaterials Research Group (TBRG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Department of Biomedical Engineering, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran
  6. 6. Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran

Source: Artificial Organs Published:2019


Abstract

This in vitro study aimed to evaluate the physicochemical and biological activity of the polycaprolactone/chitosan/collagen scaffolds incorporated with 0, 0.5, 3, and 6 wt% of graphene oxide (GO). Using standard tests and MG-63 cells, the characteristics of scaffolds were evaluated, and the behavior of osteoblasts were simulated, respectively. A non-significant decrease in nanofibers diameter was noted in scaffolds with a higher ratio of GO. The hydrophilicity and bioactivity of the scaffold surface, as well as cell attachment and proliferation, increased in correspondence to an increase in GO. The higher ratio of GO also improved the osteogenesis activity. GO increased the degradation rate, but it was negligible and seemed not enough to endanger stability. Modifying the scaffolds with GO did not make a significant change to the antibacterial effect. © 2019 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.
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