Controlling Evolution of Protein Corona: A Prosperous Approach to Improve Chitosan-Based Nanoparticle Biodistribution and Half-Life

Controlling Evolution of Protein Corona: A Prosperous Approach to Improve Chitosan-Based Nanoparticle Biodistribution and Half-Life Publisher Pubmed

Tekie FSM¹ ; Hajiramezanali M² ; Geramifar P³ ; Raoufi M⁴ ; Dinarvand R^{1, 5} ; Soleimani M^{6, 7} ; Atyabi F^{1, 5}

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1. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Radipharmacy, Faculty of pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pharmaceutical Nanotechnology, Faculty of pharmacy, Tehran university of medical sciences, Tehran, Iran
5. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran, Iran
6. Department of Molecular Biology and Genetic Engineering, Stem Cell Technology Research Center, P.O. Box 14155-3174, Tehran, Iran
7. Department of Hematology, School of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-111, Tehran, Iran

Source: Scientific reports Published:2020

Abstract

Protein corona significantly affects in vivo fate of nanoparticles including biodistribution and half-life. Without manipulating the physicochemical properties of nanoparticles with considering their biointerference, attaining effective treatment protocols is impossible. For this reason, protein corona evolution and biodistribution of different chitosan (Ch)-based nanoparticles including Ch and carboxymethyl dextran (CMD)/thiolated dextran (TD) polyelectrolyte complexes (PECs) were studied using highly precious and sensitive methods such as liquid chromatography-mass/mass (LC-MS/MS) spectroscopy and positron emission tomography/computed tomography (PET/CT) scan. The importance of serum presence/absence in culture medium with different pH and corona effect on cellular uptake of PECs investigated by in vitro study. Designed PECs have low amounts of proteins in corona mostly enriched by Apolipoproteins, protein C, hemoglobin subunits, and inter-alpha- trypsin inhibitor that beside improving uptake of nanoparticles, they have low liver uptake and notable heart blood pool accumulation that confirmed the long circulation time of the nanoparticles which is favorable for delivery of nanoparticles to the site of action and achieving required therapeutic effect.

Style	Citing Format
MLA	Tekie FSM, et al.. "Controlling Evolution of Protein Corona: A Prosperous Approach to Improve Chitosan-Based Nanoparticle Biodistribution and Half-Life." Scientific reports, vol. 10, no. 1, 2020, pp. 9664-.
APA	Tekie FSM, Hajiramezanali M, Geramifar P, Raoufi M, Dinarvand R, Soleimani M, Atyabi F (2020). Controlling Evolution of Protein Corona: A Prosperous Approach to Improve Chitosan-Based Nanoparticle Biodistribution and Half-Life. Scientific reports, 10(1), 9664-.
Chicago	Tekie FSM, Hajiramezanali M, Geramifar P, Raoufi M, Dinarvand R, Soleimani M, Atyabi F. "Controlling Evolution of Protein Corona: A Prosperous Approach to Improve Chitosan-Based Nanoparticle Biodistribution and Half-Life." Scientific reports 10, no. 1 (2020): 9664-.
Harvard	Tekie FSM et al. (2020) 'Controlling Evolution of Protein Corona: A Prosperous Approach to Improve Chitosan-Based Nanoparticle Biodistribution and Half-Life', Scientific reports, 10(1), pp. 9664-.
Vancouver	Tekie FSM, Hajiramezanali M, Geramifar P, Raoufi M, Dinarvand R, Soleimani M, et al.. Controlling Evolution of Protein Corona: A Prosperous Approach to Improve Chitosan-Based Nanoparticle Biodistribution and Half-Life. Scientific reports. 2020;10(1):9664-.
BibTex	@article{ author = {Tekie FSM and Hajiramezanali M and Geramifar P and Raoufi M and Dinarvand R and Soleimani M and Atyabi F}, title = {Controlling Evolution of Protein Corona: A Prosperous Approach to Improve Chitosan-Based Nanoparticle Biodistribution and Half-Life}, journal = {Scientific reports}, volume = {10}, number = {1}, pages = {9664-}, year = {2020} }
RIS	TY - JOUR AU - Tekie FSM AU - Hajiramezanali M AU - Geramifar P AU - Raoufi M AU - Dinarvand R AU - Soleimani M AU - Atyabi F TI - Controlling Evolution of Protein Corona: A Prosperous Approach to Improve Chitosan-Based Nanoparticle Biodistribution and Half-Life JO - Scientific reports VL - 10 IS - 1 SP - 9664 EP - PY - 2020 ER -

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