Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity

Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity Publisher

Ajdary M¹ ; Moosavi MA² ; Rahmati M³ ; Falahati M⁴ ; Mahboubi M⁵ ; Mandegary A^{6, 7} ; Jangjoo S⁸ ; Mohammadinejad R⁶ ; Varma RS⁹

Show Affiliations

1. Cellular and Molecular Research Center, Iran University of Medical Sciences, P.O. Box 1449614525, Tehran, Iran
2. Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, P.O Box 14965/161, Tehran, Iran
3. Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, P.O. Box 13145-158, Tehran, Iran
4. Department of Nanotechnology, Faculty of Advance Science and Technology, Pharmaceutical Sciences Branches, Islamic Azad University of Tehran, P.O. Box 1916893813, Tehran, Iran
5. Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Abadan School of Medical Sciences, P.O. Box 517, Abadan, Iran
6. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, P.O. Box 1355576169, Kerman, Iran
7. Neuroscience Research Center, Institute of Neuropharmacology, Department of Pharmacology & Toxicology, School of Pharmacy, Kerman University of Medical Sciences, P.O. Box 7616911319, Kerman, Iran
8. School of Medicine, International Branch, Shiraz University of Medical Sciences, Shiraz, 7134845794, Iran
9. Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacky University in Olomouc, Slechtitelu 27, Olomouc, 783 71, Czech Republic

Source: Nanomaterials Published:2018

Abstract

Nanoparticles (NPs) are currently used in diagnosis and treatment of many human diseases, including autoimmune diseases and cancer. However, cytotoxic effects of NPs on normal cells and living organs is a severe limiting factor that hinders their use in clinic. In addition, diversity of NPs and their physico-chemical properties, including particle size, shape, surface area, dispersity and protein corona effects are considered as key factors that have a crucial impact on their safe or toxicological behaviors. Current studies on toxic effects of NPs are aimed to identify the targets and mechanisms of their side effects, with a focus on elucidating the patterns of NP transport, accumulation, degradation, and elimination, in both in vitro and in vitro models. NPs can enter the body through inhalation, skin and digestive routes. Consequently, there is a need for reliable information about effects of NPs on various organs in order to reveal their efficacy and impact on health. This review covers the existing knowledge base on the subject that hopefully prepares us better to address these challenges. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

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Style	Citing Format
MLA	Ajdary M, et al.. "Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity." Nanomaterials, vol. 8, no. 9, 2018, pp. -.
APA	Ajdary M, Moosavi MA, Rahmati M, Falahati M, Mahboubi M, Mandegary A, Jangjoo S, Mohammadinejad R, Varma RS (2018). Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity. Nanomaterials, 8(9), -.
Chicago	Ajdary M, Moosavi MA, Rahmati M, Falahati M, Mahboubi M, Mandegary A, Jangjoo S, Mohammadinejad R, Varma RS. "Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity." Nanomaterials 8, no. 9 (2018): -.
Harvard	Ajdary M et al. (2018) 'Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity', Nanomaterials, 8(9), pp. -.
Vancouver	Ajdary M, Moosavi MA, Rahmati M, Falahati M, Mahboubi M, Mandegary A, et al.. Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity. Nanomaterials. 2018;8(9):-.
BibTex	@article{ author = {Ajdary M and Moosavi MA and Rahmati M and Falahati M and Mahboubi M and Mandegary A and Jangjoo S and Mohammadinejad R and Varma RS}, title = {Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity}, journal = {Nanomaterials}, volume = {8}, number = {9}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Ajdary M AU - Moosavi MA AU - Rahmati M AU - Falahati M AU - Mahboubi M AU - Mandegary A AU - Jangjoo S AU - Mohammadinejad R AU - Varma RS TI - Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity JO - Nanomaterials VL - 8 IS - 9 SP - EP - PY - 2018 ER -

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