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Synthesis and Evaluation of Coumarin-Resveratrol Hybrids As 15-Lipoxygenaze Inhibitors Publisher



Rahmaninezhad S1 ; Khosravani L1 ; Saeedi M2 ; Divsalar K3 ; Firoozpour L4 ; Pourshojaei Y1 ; Sarrafi Y5 ; Nadri H6 ; Moradi A6 ; Mahdavi M1 ; Shafiee A1 ; Foroumadi A3, 4
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Source: Synthetic Communications Published:2015


Abstract

A series of coumarin-resveratrol hybrids, 3-arylcoumarin derivatives 3a-u, were synthesized through the intermolecular condensation reaction of various salicylaldehydes and phenylacetic acids in the presence of 1,4-diazabicyclo[2.2.2]octane under solvent-free conditions. All the synthesized compounds were screened for their inhibitory potency against soybean 15-lipoxygenase. Among them, three compounds (3c, 3j, and 3q) showed good enzyme-inhibitory activities. GRAPHICAL ABSTRACT. Copyright © 2015 Taylor & Francis Group, LLC.
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