Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase

Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase Publisher Pubmed

Dianat S¹ ; Moghimi S² ; Mahdavi M³ ; Nadri H⁴ ; Moradi A⁴ ; Firoozpour L³ ; Emami S⁵ ; Mouradzadegun A¹ ; Shafiee A² ; Foroumadi A^{2, 3}

Show Affiliations

1. Department of Chemistry, Faculty of Science, Shahid Chamran University, Ahvaz, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5. Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Source: Journal of Enzyme Inhibition and Medicinal Chemistry Published:2016

Abstract

A series of 2-chloro-quinoline-based imidazopyridines 6a–l and imidazothiazoles 6m–o bearing a bulky alkylamine side chain were synthesized as soybean 15-LOX inhibitors. The target compounds 6a–o were prepared via one-pot reaction of 2-chloroquinoline-3-carbaldehyde (3), heteroaromatic amidine 4, and alkyl isocyanides 5, in the presence of NH4Cl. All compounds showed significant anti-15-LOX activity (IC50 values ≤40 μM). Among the title compounds, the imidazo[2,1-b]thiazole derivative 6n bearing a tert-butylamine moiety showed the highest activity against soybean 15-LOX enzyme. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

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Experts (# of related papers)

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Mohammad Mahdavi (5)

Alireza Foroumadi (4)

Style	Citing Format
MLA	Dianat S, et al.. "Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 31, no. , 2016, pp. 205-209.
APA	Dianat S, Moghimi S, Mahdavi M, Nadri H, Moradi A, Firoozpour L, Emami S, Mouradzadegun A, Shafiee A, Foroumadi A (2016). Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(), 205-209.
Chicago	Dianat S, Moghimi S, Mahdavi M, Nadri H, Moradi A, Firoozpour L, Emami S, Mouradzadegun A, Shafiee A, Foroumadi A. "Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase." Journal of Enzyme Inhibition and Medicinal Chemistry 31, no. (2016): 205-209.
Harvard	Dianat S et al. (2016) 'Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase', Journal of Enzyme Inhibition and Medicinal Chemistry, 31(), pp. 205-209.
Vancouver	Dianat S, Moghimi S, Mahdavi M, Nadri H, Moradi A, Firoozpour L, et al.. Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016;31():205-209.
BibTex	@article{ author = {Dianat S and Moghimi S and Mahdavi M and Nadri H and Moradi A and Firoozpour L and Emami S and Mouradzadegun A and Shafiee A and Foroumadi A}, title = {Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase}, journal = {Journal of Enzyme Inhibition and Medicinal Chemistry}, volume = {31}, number = {}, pages = {205-209}, year = {2016} }
RIS	TY - JOUR AU - Dianat S AU - Moghimi S AU - Mahdavi M AU - Nadri H AU - Moradi A AU - Firoozpour L AU - Emami S AU - Mouradzadegun A AU - Shafiee A AU - Foroumadi A TI - Quinoline-Based Imidazole-Fused Heterocycles As New Inhibitors of 15-Lipoxygenase JO - Journal of Enzyme Inhibition and Medicinal Chemistry VL - 31 IS - SP - 205 EP - 209 PY - 2016 ER -

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