Magnetic Fluid Hyperthermia in a Cylindrical Gel Contains Water Flow Publisher



Heydari M^{1, 2} ; Javidi M^{1, 2} ; Attar MM³ ; Karimi A^{1, 2} ; Navidbakhsh M^{1, 2} ; Haghpanahi M^{1, 2} ; Amanpour S⁴ Show Affiliations
Source: Journal of Mechanics in Medicine and Biology Published:2015

Abstract

In magnetic fluid hyperthermia (MFH), nanoparticles are injected into a diseased tissue and then subjected to an alternating high frequency magnetic field. The produced heat may have a key asset to destroy the cancerous cells. The blood flow in a tissue is considered as the most complicated part of the MFH which should be taken into account in the analysis of the MFH. This study was aimed to perform an experimental study to investigate the heat transfer of agar gel which contains fluid flow. Fe3O4 as a nanoparticle was injected into the center of a cylindrical gel. It was also embedded with other cylindrical gels and subjected to an alternating magnetic field of 7.3 (kA/m) and a frequency of 50 (kHz) for 3600 (s). The temperature of the gel was measured at three points. The temperature distribution was measured via the experimental data. Moreover, specific absorption rate (SAR) was quantified with time differential temperature function at t = 0 by means of experimental data. Finite element method (FEM) was employed to establish a model to validate the SAR function. Results revealed the effects of fluid flow and accuracy of the SAR function for heat production in gel. The proposed function have implications in hyperthermia studies as a heat generation source. Finally, the condition of experimental setup was simulated to find the blood perfusion. © 2015 World Scientific Publishing Company.