Evaluation of Ccr5-I32 Mutation and Hiv-1 Surveillance Drug-Resistance Mutations in Peripheral Blood Mononuclear Cells of Long-Term Non Progressors of Hiv-1-Infected Individuals

Evaluation of Ccr5-I32 Mutation and Hiv-1 Surveillance Drug-Resistance Mutations in Peripheral Blood Mononuclear Cells of Long-Term Non Progressors of Hiv-1-Infected Individuals Publisher

Khanaliha K¹ ; Bokharaeisalim F² ; Donyavi T³ ; Nahand JS⁴ ; Marjani A⁵ ; Jamshidi S² ; Khatami A² ; Moghaddas M⁶ ; Esghaei M² ; Fakhim A⁷

Show Affiliations

1. Research Center Of Pediatric Infectious Diseases, Institute Of Immunology And Infectious Diseases, Iran University Of Medical Sciences, Tehran, Iran
2. Department Of Virology, School Of Medicine, Iran University Of Medical Sciences, Tehran, Iran
3. Medical Biotechnology Department, School Of Allied Medical Sciences, Iran
4. Infectious And Tropical Diseases Research Center, Tabriz University Of Medical Sciences, Tabriz, Iran
5. Department Of Virology, School Of Public Health, Tehran University Of Medical Sciences, Tehran, Iran
6. School Of Medicine, Iran University Of Medical Sciences, Tehran, Iran
7. Department Of Architectural Engineering, Faculty Of Engineering, Islamic Azad University, South Tehran Branch, Tehran, Iran

Source: Future Virology Published:2022

Abstract

Aim: This study aimed to evaluate chemokine receptor 5 delta 32 (CCR5-δ32) mutation and HIV-1 surveillance drug-resistance mutations (SDRMs) in peripheral blood mononuclear cells of long-term non progressors (LTNPs) of HIV-1-infected individuals. Materials & methods: This research was performed on 197 treatment-naive HIV-1-infected patients. After follow-up, it was determined that 15 (7.6%) of these people were LTNPs. The PCR assay was performed to identify the CCR5 genotype and HIV-1 SDRMs. Results: One (6.7%) of the LTNPs was heterozygous (wt/δ32) for the CCR5 delta 32 (CCR5δ32). However, none of the individuals was homozygous for this mutation (δ32/δ32). Moreover, none of the LTNPs showed HIV-1 SDRMs. The CRF35-AD subtype was the most dominant subtype, with a percentage of 93.3%. Conclusion: Iranian elite controllers are negative for CCR5-delta 32 homozygous genotype and drug resistance against antiretroviral drugs. © 2022 Future Medicine Ltd.

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Style	Citing Format
MLA	Khanaliha K, et al.. "Evaluation of Ccr5-I32 Mutation and Hiv-1 Surveillance Drug-Resistance Mutations in Peripheral Blood Mononuclear Cells of Long-Term Non Progressors of Hiv-1-Infected Individuals." Future Virology, vol. 17, no. 7, 2022, pp. 429-439.
APA	Khanaliha K, Bokharaeisalim F, Donyavi T, Nahand JS, Marjani A, Jamshidi S, Khatami A, Moghaddas M, Esghaei M, Fakhim A (2022). Evaluation of Ccr5-I32 Mutation and Hiv-1 Surveillance Drug-Resistance Mutations in Peripheral Blood Mononuclear Cells of Long-Term Non Progressors of Hiv-1-Infected Individuals. Future Virology, 17(7), 429-439.
Chicago	Khanaliha K, Bokharaeisalim F, Donyavi T, Nahand JS, Marjani A, Jamshidi S, Khatami A, Moghaddas M, Esghaei M, Fakhim A. "Evaluation of Ccr5-I32 Mutation and Hiv-1 Surveillance Drug-Resistance Mutations in Peripheral Blood Mononuclear Cells of Long-Term Non Progressors of Hiv-1-Infected Individuals." Future Virology 17, no. 7 (2022): 429-439.
Harvard	Khanaliha K et al. (2022) 'Evaluation of Ccr5-I32 Mutation and Hiv-1 Surveillance Drug-Resistance Mutations in Peripheral Blood Mononuclear Cells of Long-Term Non Progressors of Hiv-1-Infected Individuals', Future Virology, 17(7), pp. 429-439.
Vancouver	Khanaliha K, Bokharaeisalim F, Donyavi T, Nahand JS, Marjani A, Jamshidi S, et al.. Evaluation of Ccr5-I32 Mutation and Hiv-1 Surveillance Drug-Resistance Mutations in Peripheral Blood Mononuclear Cells of Long-Term Non Progressors of Hiv-1-Infected Individuals. Future Virology. 2022;17(7):429-439.
BibTex	@article{ author = {Khanaliha K and Bokharaeisalim F and Donyavi T and Nahand JS and Marjani A and Jamshidi S and Khatami A and Moghaddas M and Esghaei M and Fakhim A}, title = {Evaluation of Ccr5-I32 Mutation and Hiv-1 Surveillance Drug-Resistance Mutations in Peripheral Blood Mononuclear Cells of Long-Term Non Progressors of Hiv-1-Infected Individuals}, journal = {Future Virology}, volume = {17}, number = {7}, pages = {429-439}, year = {2022} }
RIS	TY - JOUR AU - Khanaliha K AU - Bokharaeisalim F AU - Donyavi T AU - Nahand JS AU - Marjani A AU - Jamshidi S AU - Khatami A AU - Moghaddas M AU - Esghaei M AU - Fakhim A TI - Evaluation of Ccr5-I32 Mutation and Hiv-1 Surveillance Drug-Resistance Mutations in Peripheral Blood Mononuclear Cells of Long-Term Non Progressors of Hiv-1-Infected Individuals JO - Future Virology VL - 17 IS - 7 SP - 429 EP - 439 PY - 2022 ER -

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