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Biomimetic Engineered Approaches for Neural Tissue Engineering: Spinal Cord Injury Publisher Pubmed



Pourkhodadad S1 ; Hosseinkazemi H2 ; Bonakdar S1 ; Nekounam H3
Authors
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Authors Affiliations
  1. 1. National Cell Bank Department, Pasteur Institute of Iran, Tehran, Iran
  2. 2. Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran
  3. 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Biomedical Materials Research - Part B Applied Biomaterials Published:2023


Abstract

The healing process for spinal cord injuries is complex and presents many challenges. Current advances in nerve regeneration are based on promising tissue engineering techniques, However, the chances of success depend on better mimicking the extracellular matrix (ECM) of neural tissue and better supporting neurons in a three-dimensional environment. The ECM provides excellent biological conditions, including desirable morphological features, electrical conductivity, and chemical compositions for neuron attachment, proliferation and function. This review outlines the rationale for developing a construct for neuron regrowth in spinal cord injury using appropriate biomaterials and scaffolding techniques. © 2022 Wiley Periodicals LLC.
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