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Interplay Between Angiogenesis and Neurogenesis in Nerve Regeneration Publisher



Namini MS1 ; Ebrahimibarough S1 ; Daneshimehr F1 ; Ai J1
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Biomaterials for Vasculogenesis and Angiogenesis Published:2022


Abstract

Various studies have been conducted to induce vascularization in nerve lesions for its prominent role in promoting the remodeling process by using the factors and cells involved in regeneration also sustaining cell survival in order to decrease the chance for central necrosis in large nerve grafts. Although several approaches have been developed to provide vascularized nerve grafts, limited donor sites are still a challenge. Tissue engineering is a newly emerged alternative to tackle the problems pertaining to conventional techniques by prefabricating nerve grafts. Herein, various methods of preparing nerve grafts in both conventional and tissue engineering approaches with focus on the latter are discussed. At first, we describe the nerve regeneration in nervous system, and then we focus on neural tissue engineering strategies for repair of injured CNS and PNS. We also describ the role of angiogenesis in the regeneration and induction of this process in engineered tissues. © 2022 Elsevier Ltd. All rights reserved.
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