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The Association Between Obesity With Serum Levels of Liver Enzymes, Alanine Aminotransferase, Aspartate Aminotransferase, Alkaline Phosphatase and Gamma-Glutamyl Transferase in Adult Women Publisher Pubmed



Jalili V1 ; Poorahmadi Z2 ; Hasanpour Ardekanizadeh N3 ; Gholamalizadeh M4 ; Ajami M5 ; Houshiarrad A6 ; Hajipour A7 ; Shafie F8 ; Alizadeh A9 ; Mokhtari Z10 ; Shafaei H11 ; Esmaeili M12 ; Doaei S13
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine, Urmia University of Medical sciences, Urmia, Iran
  2. 2. Department of Food and Beverage Products, Food and Drug Administration, Tehran, Iran
  3. 3. Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Food and Nutrition Policy and Planning, National Nutrition and Food Technology Research Institute, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Nutrition Research, National Nutrition and Food Technology Research Institute, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Science, Tehran, Iran
  7. 7. School of Health, Qazvin University of Medical Sciences, Qazvin, Iran
  8. 8. Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9. Department of Pharmacologynosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  11. 11. Nursing and Midwifery School, Guilan University of Medical Sciences, Rasht, Iran
  12. 12. Department of Nutrition Research, National Nutrition and Food Technology Research Institute, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  13. 13. Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Endocrinology# Diabetes and Metabolism Published:2022


Abstract

Background: Obesity-induced inflammation may independently disturb the function of critical organs such as liver. This study aimed to investigate the association of obesity with serum levels of biomarkers of liver function including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) in adult women. Methods: This cross-sectional study was carried out on 360 adult women in the summer of 2020 in Tehran, Iran. The participants were categorized into two groups based on their body mass index (BMI≤29.9 and BMI > 30). The serum levels of ALT, AST, ALP and GGT were measured. Logistic regression method was used to assess the association between BMI and liver enzymes after adjusting for the confounders. Results: The mean BMI in non-obese and obese groups was 26.32 ± 2.61 and 33.40 ± 2.80 kg/m2, respectively (p =.01). A significant association was found between BMI with ALT (β =.16, p =.002) and GGT (β =.19, p =.01) enzymes after adjustment for age. The association between BMI and GGT remained significant after further adjustments for smoking, alcohol use, physical activity and educational status. There was no significant association between BMI and liver enzymes after adjustment for dietary intake. Conclusions: Obesity was associated with the level of serum liver enzymes. However, adjustment for dietary intake disappeared the significant results. Further studies are needed to determine the independent effects of obesity on the liver function. © 2022 The Authors. Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd.