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Association of Circulating Adipokines With Metabolic Dyslipidemia in Obese Versus Non-Obese Individuals Publisher Pubmed



Rahimlou M1 ; Mirzaei K1 ; Keshavarz SA2 ; Hosseinnezhad A3, 4
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medicine, Section of Endocrinology, Nutrition, Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, 02118, MA, United States

Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2016


Abstract

Aim Previous studies have shown that circulating adipokines may play an important role in the pathogenesis of some obesity related chronic disease such as dyslipidemia and type2 diabetes mellitus. The aim of the present study was to investigate the association between vaspin, omentin-1 and retinol binding protein-4 levels with metabolic dyslipidemia (MD) criteria in obese and non-obese individuals. Method The study was conducted on 170 obese and 81 non-obese individuals. After collecting the blood samples, serum levels metabolic parameters as well as three circulating adipokines and body composition were measured. Results No significant difference was noted regarding the mean serum levels of omentin-1 and vaspin between the obese and non-obese groups, while, serum level of RBP4 was significantly higher in the non-obese group. We found the 0.22 increased risk of MD in obese individuals with higher RBP4 concentration. After the adjustment for confounding factors, this association was still significant. No significant association was noted between MD and its components relative risks with omentin-1 and vaspin levels. Conclusion Our study demonstrated that circulating RBP4 was significantly higher in the obese individuals which may increase the risk of MD in them. Further researches are needed to address this association. © 2015 Diabetes India
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1. Mediatory Effect of Circulating Vaspin on Resting Metabolic Rate in Obese Individuals, European Journal of Nutrition (2016)
2. Retinol Binding Protein 4 in Relation to Diet, Inflammation, Immunity, and Cardiovascular Diseases, Advances in Nutrition (2015)
3. Associations of Dietary Fats Intake and Adipokines Levels in Obese Women, Clinical Nutrition ESPEN (2021)
4. The Association Between Serum Omentin Level and Bodyweight: A Systematic Review and Meta-Analysis of Observational Studies, Clinical Nutrition ESPEN (2020)
5. The Comparison of Serum Vaspin and Visfatin Concentrations in Obese and Normal Weight Women, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2015)
6. Possible Resting Metabolic Rate Modification by the Circulating Rbp4 in Obese Subjects, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2015)
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