Biotin Decorated Plga Nanoparticles Containing Sn-38 Designed for Cancer Therapy

Biotin Decorated Plga Nanoparticles Containing Sn-38 Designed for Cancer Therapy Publisher Pubmed

Mehdizadeh M¹ ; Rouhani H^{1, 2} ; Sepehri N^{1, 2} ; Varshochian R^{1, 3} ; Ghahremani MH⁴ ; Amini M⁵ ; Gharghabi M⁴ ; Ostad SN⁴ ; Atyabi F^{1, 3} ; Baharian A¹ ; Dinarvand R^{1, 3}

Show Affiliations

1. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Nano Alvand Co., Avicenna Tech Park, Tehran University of Medical Sciences, Tehran, Iran
3. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Toxicology-Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2017

Abstract

Active targeted chemotherapy is expected to provide more specific delivery of cytotoxic drugs to the tumor cells and hence reducing the side effects on healthy tissues. Due to the over expression of biotin receptors on cancerous cells as a result of further requirement for rapid proliferations, biotin can be a good candidate as a targeting agent. In this study, biotin decorated PLGA nanoparticles (NPs) containing SN-38 were prepared and in vitro studies were evaluated for their improved anti-cancer properties. In conclusion, biotin targeted PLGA NPs containing SN-38 showed preferential anticancer properties against tumor cells with biotin receptor over expression. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

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Rassoul Dinarvand (11)

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Style	Citing Format
MLA	Mehdizadeh M, et al.. "Biotin Decorated Plga Nanoparticles Containing Sn-38 Designed for Cancer Therapy." Artificial Cells# Nanomedicine and Biotechnology, vol. 45, no. 3, 2017, pp. 495-504.
APA	Mehdizadeh M, Rouhani H, Sepehri N, Varshochian R, Ghahremani MH, Amini M, Gharghabi M, Ostad SN, Atyabi F, Baharian A, Dinarvand R (2017). Biotin Decorated Plga Nanoparticles Containing Sn-38 Designed for Cancer Therapy. Artificial Cells# Nanomedicine and Biotechnology, 45(3), 495-504.
Chicago	Mehdizadeh M, Rouhani H, Sepehri N, Varshochian R, Ghahremani MH, Amini M, Gharghabi M, et al.. "Biotin Decorated Plga Nanoparticles Containing Sn-38 Designed for Cancer Therapy." Artificial Cells# Nanomedicine and Biotechnology 45, no. 3 (2017): 495-504.
Harvard	Mehdizadeh M et al. (2017) 'Biotin Decorated Plga Nanoparticles Containing Sn-38 Designed for Cancer Therapy', Artificial Cells# Nanomedicine and Biotechnology, 45(3), pp. 495-504.
Vancouver	Mehdizadeh M, Rouhani H, Sepehri N, Varshochian R, Ghahremani MH, Amini M, et al.. Biotin Decorated Plga Nanoparticles Containing Sn-38 Designed for Cancer Therapy. Artificial Cells# Nanomedicine and Biotechnology. 2017;45(3):495-504.
BibTex	@article{ author = {Mehdizadeh M and Rouhani H and Sepehri N and Varshochian R and Ghahremani MH and Amini M and Gharghabi M and Ostad SN and Atyabi F and Baharian A and Dinarvand R}, title = {Biotin Decorated Plga Nanoparticles Containing Sn-38 Designed for Cancer Therapy}, journal = {Artificial Cells# Nanomedicine and Biotechnology}, volume = {45}, number = {3}, pages = {495-504}, year = {2017} }
RIS	TY - JOUR AU - Mehdizadeh M AU - Rouhani H AU - Sepehri N AU - Varshochian R AU - Ghahremani MH AU - Amini M AU - Gharghabi M AU - Ostad SN AU - Atyabi F AU - Baharian A AU - Dinarvand R TI - Biotin Decorated Plga Nanoparticles Containing Sn-38 Designed for Cancer Therapy JO - Artificial Cells# Nanomedicine and Biotechnology VL - 45 IS - 3 SP - 495 EP - 504 PY - 2017 ER -

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