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Silk Fibroin Nanoparticle As a Novel Drug Delivery System Publisher Pubmed



Mottaghitalab F1 ; Farokhi M2 ; Shokrgozar MA2 ; Atyabi F3 ; Hosseinkhani H4, 5
Authors
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Authors Affiliations
  1. 1. Nanotechnology Research Center, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14174, Iran
  4. 4. Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan
  5. 5. Center of Excellence in Nanomedicine, National Taiwan University of Science and Technology, Taipei, 10607, Taiwan

Source: Journal of Controlled Release Published:2015


Abstract

Design and synthesis of efficient drug delivery systems are of vital importance for medicine and healthcare. Nanocarrier-based drug delivery systems, in particular nanoparticles, have generated great excitement in the field of drug delivery since they provide new opportunities to overcome the limitations of conventional delivery methods with regards to the drugs. Silk fibroin (SF) is a naturally occurring protein polymer with several unique properties that make it a suitable material for incorporation into a variety of drug delivery vehicles capable of delivering a range of therapeutic agents. SF matrices have been shown to successfully deliver anticancer drugs, small molecules, and biomolecules. This review will provide an in-depth discussion of the development of SF nanoparticle-based drug delivery systems. © 2015 Elsevier B.V. All rights reserved.
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