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Cytokine Levels in Patients With Β-Thalassemia Major and Healthy Individuals: A Systematic Review and Meta-Analysis Publisher Pubmed



Haghpanah S1 ; Hosseinibensenjan M1 ; Sayadi M2 ; Nozari F1 ; Ramzi M1 ; Cohan N1 ; Rezaei N3, 4, 5
Authors
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Authors Affiliations
  1. 1. Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Cardiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Clinical Laboratory Published:2022


Abstract

Background: Cytokine levels in patients with β-thalassemia major (β-TM) have been assessed in several studies. Accordingly, a wide variety of immune disturbances has been shown in patients with thalassemia. Recurrent transfusions cause iron overload, which induces an increase in the production of cytokines. However, no systematic approach or meta-analysis has been done to provide a clear feature of cytokine levels in β-TM. The present meta-analysis aimed to summarize the existing evidence regarding different levels of cytokines in patients with Β-TM compared to healthy controls. Methods: This study was performed according to the PRISMA checklist. A systematic search was done in Web of Science (ISI), Scopus, and PubMed databases. The quality of the included studies was assessed based on the Newcastle-Ottawa Scale. Meta-analysis was run via STATA 13 software. The standardized mean difference was considered the effect size for comparing the continuous variables. Results: This meta-analysis included 16 studies conducted on 805 β-TM patients and 624 healthy individuals (with the mean age of 16.10 ± 4.33 and 16.22 ± 3.78, respectively). The results showed significantly higher levels of Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), and IL-10 in patients with β-TM compared to the healthy controls. Conclusion: The results indicated that the levels of both inflammatory and anti-inflammatory cytokines were higher in patients with β-TM compared to the healthy population, which could be associated with higher levels of oxidative markers in these patients. Further studies are suggested to evaluate the difference in cytokine levels among different types of thalassemia. © 2022 Verlag Klinisches Labor GmbH. All rights reserved.
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