The Effect of Quercetin on Iron Overload and Inflammation in Β-Thalassemia Major Patients: A Double-Blind Randomized Clinical Trial

The Effect of Quercetin on Iron Overload and Inflammation in Β-Thalassemia Major Patients: A Double-Blind Randomized Clinical Trial Publisher Pubmed

Sajadi Hezaveh Z¹ ; Azarkeivan A² ; Janani L³ ; Hosseini S⁴ ; Shidfar F¹

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1. Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
2. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
3. Department of Epidemiology and Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
4. Department of Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Source: Complementary Therapies in Medicine Published:2019

Abstract

Objectives: The aim of this study was to determine whether quercetin can reduce iron overload and inflammation in thalassemic patients. Methods: Eighty four patients were recruited to this study and randomly assigned to two groups: 42 patients received a 500 mg/day quercetin tablet and 42 others took a 500 mg/day starch placebo for 12 weeks. Demographic, anthropometric and biochemical evaluation were performed. Results: ANCOVA analysis revealed that compared to the control group, quercetin could reduce high sensitivity C-reactive protein (hs-CRP) (P = 0.046), iron (p = 0.036), ferritin (p = 0.043), and transferrin saturation (TS) (p = 0.008) and increase transferrin (p = 0.045) significantly, but it had no significant effect on total iron binding capacity (TIBC) (p = 0.734) and tumor necrosis factor α (TNF-α) (p = 0.310). Conclusions: Quercetin could ameliorate the iron status in thalassemia major, but its effect on inflammation is indistinctive. © 2019 Elsevier Ltd

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Style	Citing Format
MLA	Sajadi Hezaveh Z, et al.. "The Effect of Quercetin on Iron Overload and Inflammation in Β-Thalassemia Major Patients: A Double-Blind Randomized Clinical Trial." Complementary Therapies in Medicine, vol. 46, no. , 2019, pp. 24-28.
APA	Sajadi Hezaveh Z, Azarkeivan A, Janani L, Hosseini S, Shidfar F (2019). The Effect of Quercetin on Iron Overload and Inflammation in Β-Thalassemia Major Patients: A Double-Blind Randomized Clinical Trial. Complementary Therapies in Medicine, 46(), 24-28.
Chicago	Sajadi Hezaveh Z, Azarkeivan A, Janani L, Hosseini S, Shidfar F. "The Effect of Quercetin on Iron Overload and Inflammation in Β-Thalassemia Major Patients: A Double-Blind Randomized Clinical Trial." Complementary Therapies in Medicine 46, no. (2019): 24-28.
Harvard	Sajadi Hezaveh Z et al. (2019) 'The Effect of Quercetin on Iron Overload and Inflammation in Β-Thalassemia Major Patients: A Double-Blind Randomized Clinical Trial', Complementary Therapies in Medicine, 46(), pp. 24-28.
Vancouver	Sajadi Hezaveh Z, Azarkeivan A, Janani L, Hosseini S, Shidfar F. The Effect of Quercetin on Iron Overload and Inflammation in Β-Thalassemia Major Patients: A Double-Blind Randomized Clinical Trial. Complementary Therapies in Medicine. 2019;46():24-28.
BibTex	@article{ author = {Sajadi Hezaveh Z and Azarkeivan A and Janani L and Hosseini S and Shidfar F}, title = {The Effect of Quercetin on Iron Overload and Inflammation in Β-Thalassemia Major Patients: A Double-Blind Randomized Clinical Trial}, journal = {Complementary Therapies in Medicine}, volume = {46}, number = {}, pages = {24-28}, year = {2019} }
RIS	TY - JOUR AU - Sajadi Hezaveh Z AU - Azarkeivan A AU - Janani L AU - Hosseini S AU - Shidfar F TI - The Effect of Quercetin on Iron Overload and Inflammation in Β-Thalassemia Major Patients: A Double-Blind Randomized Clinical Trial JO - Complementary Therapies in Medicine VL - 46 IS - SP - 24 EP - 28 PY - 2019 ER -

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