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Impact of Covid-19 and Vaccination on First and Second Trimester Screening Results Publisher Pubmed



Hantoushzadeh S1 ; Younesi S2 ; Mahdi Taheri Amin M2 ; Saadati P2 ; Jamali S2 ; Nassiri S3 ; Modarresi MH4 ; Savad S2 ; Delshad S2 ; Soleiman Meiguni Z1 ; Amidi S2 ; Navidpour F2 ; Yazdani B2 ; Karimi Farani A5 Show All Authors
Authors
  1. Hantoushzadeh S1
  2. Younesi S2
  3. Mahdi Taheri Amin M2
  4. Saadati P2
  5. Jamali S2
  6. Nassiri S3
  7. Modarresi MH4
  8. Savad S2
  9. Delshad S2
  10. Soleiman Meiguni Z1
  11. Amidi S2
  12. Navidpour F2
  13. Yazdani B2
  14. Karimi Farani A5
  15. Saleh M3
  16. Ghafourifard S6
Show Affiliations
Authors Affiliations
  1. 1. Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Nilouu Laboratory, Tehran, Iran
  3. 3. Department of Gynecology and Obstetrics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Dentistry Faculty, Tehran University of Medical Sciences, Teharn, Iran
  6. 6. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Cytokine Published:2023


Abstract

COVID-19 has been shown to affect pregnant women. Since pregnant women are at risk of this infection, vaccination against COVID-19 has been suggested as an imperative way to diminish rate of COVID-19 in this population. In the current observational study, we have collected data of first and second trimester screening (FTS and STS) from pregnant women who were infected with SARS-CoV-2 and/or vaccinated against COVID-19 during their pregnancy, and compared this data with a group of control pregnant women. The cohort included 4612 and 2426 women referred for FTS and STS, respectively. There was no significant difference in median values of Pregnancy-associated plasma protein A (PAPP-A) and human chorionic gonadotropin-beta subunit (βHCG) between infected women and controls. Moreover, these levels were not different between “Infected + vaccinated” and “Only vaccinated” groups. However, median values of PAPP-A and βHCG were higher in “Infected + vaccinated” and “Only vaccinated” groups compared with “Infected” and “Control” groups (P < 0.001). Median values of unconjugated Estriol (uE3) and βHCG markers were not different between “Only vaccinated” and “Control” groups, yet both markers were elevated in “Infected” and “Infected + vaccinated” groups compared with other groups. AFP values were higher in “Infected” group (P = 0.012). However, multiple of the median (MoM) and risk of open spina bifida (OSB) were not affected. Finally, median of calculated risk of trisomy 18 was lower in “Infected” and “Vaccinated” groups compared with controls (P = 0.007). Moreover, AstraZeneca and Sinopharm vaccines were associated with elevation of the calculated risk values of trisomy 21 and trisomy 18 (P < 0.001). While Sinopharm did not affect nuchal translucency (NT) and NT MoM (P = 0.13), AstraZeneca and Barakat increased and decreased these values, respectively (P values = 0.0027 and 0.015, respectively). Taken together, COVID-19 during pregnancy might be associated with some adverse obstetric outcomes. Besides, vaccination against this infection might affect the results of STS or FTS. © 2023 Elsevier Ltd
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2. Evaluation of Pregnancy Outcomes in Mothers With Covid-19 Infection: A Systematic Review and Meta-Analysis, Journal of Obstetrics and Gynaecology (2023)
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