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Prophylactic Role of Some Plants and Phytochemicals Against Radio-Genotoxicity in Human Lymphocytes Publisher Pubmed



Cheki M1 ; Mihandoost E2 ; Shirazi A1 ; Mahmoudzadeh A3
Authors
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Authors Affiliations
  1. 1. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Poursina Avenue, Tehran, Iran
  2. 2. Novin Medical Radiation Institute, Tehran, Iran
  3. 3. Department of Radiology and Medical Physics, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Journal of Cancer Research and Therapeutics Published:2016


Abstract

Genotoxicity in lymphocytes of cancer patients undergoing radiotherapy can lead to lymphocytopenia. Lymphocytopenia induced by radiotherapy is one of the most unfavorable prognostic biological markers in cancer patients, since it has been accepted to be associated with poor prognosis in terms of both survival time and response to cancer therapy. Therefore, reduction in lymphocytopenia may increase treatment efficiency. Research endeavors with synthetic radioprotectors in the past have met with little success primarily due to toxicity-related problems. These disadvantages have led to interest on the use of some plants and phytochemicals as radioprotector. The aim of this paper is to review protective role of some plants and phytochemicals against genotoxicity-induced by ionizing radiation in human blood lymphocytes. Therefore, current review may help the future researches to decrease lymphocytopenia in radiotherapeutic clinical trials.
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