Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Synergistic Effect Between D-Ap5 and Muscimol in the Nucleus Accumbens Shell on Memory Consolidation Deficit in Adult Male Wistar Rats: An Isobologram Analysis Publisher Pubmed



Nasehi M1 ; Ostadi E2 ; Khakpai F1 ; Ebrahimighiri M3 ; Zarrindast MR4, 5, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  2. 2. Department of Pharmacology and Toxicology, Islamic Azad University, Pharmaceutical Science Branch (IAUPS), Tehran, Iran
  3. 3. Department of Biology, Faculty of Sciences, University of Zanjan, Zanjan, Iran
  4. 4. Iranian National Center for Addiction Studies (INCAS), Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran

Source: Neurobiology of Learning and Memory Published:2017


Abstract

The nucleus accumbens (NAc) glutamatergic and GABAergic systems are involved in memory processes. This study was investigated the involvement of NAc shell GABAergic system on D-AP5 induced memory consolidation deficit. The elevated plus-maze (EPM) test-retest paradigm was employed to assess memory in adult male Wistar rats. The results indicated that post-training intra-NAc shell injection of bicuculline (GABAA receptor antagonist) did not alter emotional memory consolidation. However, post-training intra-NAc shell microinjection of muscimol (GABAA receptor agonist, 0.1 μg/rat) and D-AP5 (a competitive NMDA receptor antagonist, 4 μg/rat) decreased emotional memory consolidation, suggesting the drugs induced amnesia. Moreover, a sub-threshold dose of muscimol (0.05 μg/rat) potentiated the D-AP5 (2 μg/rat) response on memory consolidation impairment. On the other hand, the middle dose of bicuculline (0.25 μg/rat) reversed memory impairment induced by D-AP5 at the higher dose. Interestingly, there is a synergistic effect between D-AP5 and muscimol on impairment of emotional memory consolidation. None of the above doses changed the locomotor activity. Our results suggest that the glutamatergic and GABAergic neurons of the NAc shell interact with each other for modulation of emotional memory consolidation. © 2017 Elsevier Inc.
Related Docs
View other Related Docs
1. Additive Effect of Harmane and Muscimol for Memory Consolidation Impairment in Inhibitory Avoidance Task, Neuroscience (2016)
2. Effect of Nucleus Accumbens Shell 5-Ht4 Receptors on the Impairment of Acpa-Induced Emotional Memory Consolidation in Male Wistar Rats, Behavioural Pharmacology (2016)
3. How Do Stupendous Cannabinoids Modulate Memory Processing Via Affecting Neurotransmitter Systems?, Neuroscience and Biobehavioral Reviews (2021)
4. The Effects of Gabaa and Nmda Receptors in the Shell-Accumbens on Spatial Memory of Meth-Treated Rats, Pharmacology Biochemistry and Behavior (2016)
5. The Role of Ca3 Gabaa Receptors on Anxiolytic-Like Behaviors and Avoidance Memory Deficit Induced by Nmda Receptor Antagonists, Journal of Psychopharmacology (2016)
6. Dorsal Hippocampal Cannabinergic and Gabaergic Systems Modulate Memory Consolidation in Passive Avoidance Task, Brain Research Bulletin (2018)
7. Role of Ca1 Gabaa and Gabab Receptors on Learning Deficit Induced by D-Ap5 in Passive Avoidance Step-Through Task, Brain Research (2018)
8. Additive Effect of Bla Gabaa Receptor Mechanism and (+)-Mk-801 on Memory Retention Deficit, an Isobologram Analysis, Pharmacology Biochemistry and Behavior (2016)
Experts (# of related papers)
View all Related Experts
Maryam Farahmandfar (3)
Nasim Vousooghi (3)
Other Related Docs
9. Methamphetamine-Induced Enhancement of Hippocampal Long-Term Potentiation Is Modulated by Nmda and Gaba Receptors in the Shell–Accumbens, Synapse (2016)
10. The Modulatory Role of Dopamine in Anxiety-Like Behavior, Archives of Iranian Medicine (2015)
11. The Modulatory Effect of Ca1 Gabab Receptors on Ketamine-Induced Spatial and Non-Spatial Novelty Detection Deficits With Respect to Ca2+, Neuroscience (2015)
12. Synergistic Effect Between Prelimbic 5-Ht3 and Cb1 Receptors on Memory Consolidation Deficit in Adult Male Sprague-Dawley Rats: An Isobologram Analysis, Neuroscience (2016)
13. Involvement of Medial Prefrontal Cortex Alpha-2 Adrenoceptors on Memory Acquisition Deficit Induced by Arachidonylcyclopropylamide, a Cannabinoid Cb1 Receptor Agonist, in Rats; Possible Involvement of Ca2+ Channels, Journal of Psychopharmacology (2016)
14. Recovery From Ketamine-Induced Amnesia by Blockade of Gaba-A Receptor in the Medial Prefrontal Cortex of Mice, Neuroscience (2017)
15. The Role of 5-Ht4 Serotonin Receptors in the Ca1 Hippocampal Region on Memory Acquisition Impairment Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Physiology and Behavior (2020)
16. Possible Involvement of the Ca1 Gabaergic System on Harmaline Induced Memory Consolidation Deficit, Brain Research Bulletin (2017)
17. The Involvement of Medial Septum 5-Ht1 and 5-Ht2 Receptors on Acpa-Induced Memory Consolidation Deficit: Possible Role of Trpc3, Trpc6 and Trpv2, Journal of Psychopharmacology (2015)
18. Critical Role of Ca1 Muscarinic Receptors on Memory Acquisition Deficit Induced by Total (Tsd) and Rem Sleep Deprivation (Rsd), Progress in Neuro-Psychopharmacology and Biological Psychiatry (2017)
19. The Effect of 5-Ht4 Serotonin Receptors in the Ca3 Hippocampal Region on D-Ap5-Induced Anxiolytic-Like Effects: Isobolographic Analyses, Behavioural Brain Research (2021)
20. The Modulatory Role of Accumbens and Hippocampus D2 Receptors in Anxiety and Memory, Naunyn-Schmiedeberg's Archives of Pharmacology (2018)
21. The Role of Ventral Hippocampal (Ca3) 5-Ht4 Receptor in Rats Emotional Memory in Elevated Plus-Maze Task, Journal of Veterinary Research (2018)
22. The Effect of Ca1 Α2 Adrenergic Receptors on Memory Retention Deficit Induced by Total Sleep Deprivation and the Reversal of Circadian Rhythm in a Rat Model, Neurobiology of Learning and Memory (2016)
23. Different Role of Ca1 5Ht3 Serotonin Receptors on Memory Acquisition Deficit Induced Total(Tsd) and Rem Sleep Deprivation(Rsd), Archives of Iranian Medicine (2017)
24. Possible Interaction Between the Ventral Hippocampal Cannabinoid Cb2 and Muscarinic Acetylcholine Receptors on the Modulation of Memory Consolidation in Mice, NeuroReport (2020)
25. The Role of Nmda Receptors of the Medial Septum and Dorsal Hippocampus on Memory Acquisition, Pharmacology Biochemistry and Behavior (2016)
26. State-Dependent Memory and Its Modulation by Different Brain Areas and Neurotransmitters, EXCLI Journal (2020)
27. The Modulatory Role of Nicotine on Cognitive and Non-Cognitive Functions, Brain Research (2019)
28. The Effect of Ca1 Dopaminergic System on Amnesia Induced by Harmane in Mice, Acta Neurologica Belgica (2019)
29. The Interaction Effect of Sleep Deprivation and Cannabinoid Type 1 Receptor in the Ca1 Hippocampal Region on Passive Avoidance Memory, Depressive-Like Behavior and Locomotor Activity in Rats, Behavioural Brain Research (2021)
30. 5-Ht1a Receptor Blockade Targeting the Basolateral Amygdala Improved Stress-Induced Impairment of Memory Consolidation and Retrieval in Rats, Neuroscience (2015)
31. The Role of Ca3 Gabab Receptors on Anxiolytic-Like Behaviors and Avoidance Memory Deficit Induced by D-Ap5 With Respect to Ca2 + Ions, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2017)
32. Activation and Inactivation of Nicotinic Receptnors in the Dorsal Hippocampal Region Restored Negative Effects of Total (Tsd) and Rem Sleep Deprivation (Rsd) on Memory Acquisition, Locomotor Activity and Pain Perception, Neuroscience (2020)
33. The Effect of Bla Gabaa Receptors in Anxiolytic-Like Effect and Aversive Memory Deficit Induced by Acpa, EXCLI Journal (2015)
34. The Effects of Ca1 5Ht4 Receptors in Mk801-Induced Amnesia and Hyperlocomotion, Neuroscience Letters (2015)
35. The Effects of Intra-Dorsal Hippocampus Infusion of Pregnenolone Sulfate on Memory Function and Hippocampal Bdnf Mrna Expression of Biliary Cirrhosis-Induced Memory Impairment in Rats, Neuroscience (2015)
36. Interplay Between Serotonin and Cannabinoid Function in the Amygdala in Fear Conditioning, Brain Research (2016)
37. Interaction Between Nmda and Cb2 Function in the Dorsal Hippocampus on Memory Consolidation Impairment: An Isobologram Analysis, Psychopharmacology (2017)
38. Role of the Amygdala Gaba-A Receptors in Acpa-Induced Deficits During Conditioned Fear Learning, Brain Research Bulletin (2017)
39. The Bidirectional Effect of Prelimbic 5-Hydroxytryptamine Type-4 (5-Ht4) Receptors on Acpa-Mediated Aversive Memory Impairment in Adult Male Sprague-Dawley Rats, Iranian Journal of Basic Medical Sciences (2021)
40. Transient Inactivation of the Nucleus Accumbens (Nac) Shell Prominently Ameliorates Responses to Acute Stress in Female Rats, Brain Research (2016)
41. The Role of Calcium-Calmodulin-Dependent Protein Kinase Ii in Modulation of Spatial Memory in Morphine Sensitized Rats, Behavioural Brain Research (2019)
42. Effects of Morphine and Maternal Care on Behaviors and Protein Expression of Male Offspring, Neuroscience (2021)
43. Possible Interaction of Hippocampal Nitric Oxide and Calcium/Calmodulin-Dependent Protein Kinase Ii on Reversal of Spatial Memory Impairment Induced by Morphine, European Journal of Pharmacology (2015)
44. Possible Involvement of the Ca1 Gabaa Receptors Upon Acquisition and Expression of the Acpa-Induced Place Preference in Mice, Physiology and Behavior (2016)
45. Dorsal Hippocampal Nmda Receptors Mediate the Interactive Effects of Arachidonylcyclopropylamide and Mdma/Ecstasy on Memory Retrieval in Rats, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2016)
46. Modulation of Cannabinoid Signaling by Hippocampal 5-Ht4 Serotonergic System in Fear Conditioning, Journal of Psychopharmacology (2016)
47. Interaction Between Hippocampal Serotonin and Cannabinoid Systems in Reactivity to Spatial and Object Novelty Detection, Behavioural Brain Research (2017)
48. Activation of Endocannabinoid System in the Rat Basolateral Amygdala Improved Scopolamine-Induced Memory Consolidation Impairment, Behavioural Brain Research (2016)
49. Activation of Trpv1 Receptors Affects Memory Function and Hippocampal Trpv1 and Creb Mrna Expression in a Rat Model of Biliary Cirrhosis, Neurological Research (2018)
50. The Effect of Gaba-B Receptors in the Basolateral Amygdala on Passive Avoidance Memory Impairment Induced by Mk-801 in Rats, Behavioural Brain Research (2021)