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Effect of Nucleus Accumbens Shell 5-Ht4 Receptors on the Impairment of Acpa-Induced Emotional Memory Consolidation in Male Wistar Rats Publisher Pubmed



Khodayar E1 ; Oryan S1 ; Nasehi M2 ; Zarrindast MR2, 3, 4, 5
Authors
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Authors Affiliations
  1. 1. Department of Biology, Faculty of Basic Sciences, Kharazmi (Tarbiat Moalem) University, Tehran, Iran
  2. 2. Cognitive and Neuroscience Research Center (CNRC), Medical Genomics Research Center, School of Advanced Sciences in Medicine, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, PO Box 13145-784, Tehran, Iran
  4. 4. Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran

Source: Behavioural Pharmacology Published:2016


Abstract

The present study investigates the effects of 5-HT4 receptors of the nucleus accumbens (NAc) shell on the impairment of emotional memory consolidation induced by cannabinoid CB1 receptor stimulation. The elevated plus maze test-retest paradigm was used to assess memory in adult male Wistar rats. Intra-NAc shell administration of ACPA (selective cannabinoid CB1 receptor agonist 0.006 μg/rat) and RS23597 (5-HT4 receptor antagonist 0.01 μg/rat), immediately after training, decreased emotional memory consolidation, suggesting a drug-induced amnesia, whereas post-training intra-NAc shell microinjections of RS67333 (5-HT4 receptor agonist 0.016 μg/rat) increased emotional memory consolidation. Interestingly, RS67333 exerted a dual effect on ACPA-induced behaviors, potentiating and restoring amnesia caused by the subthreshold and effective doses of ACPA, respectively. However, neither RS23597 nor AM251 (CB1 receptor antagonist 30, 60 and 120 ng/rat) affected emotional memory consolidation. Nonetheless, a subthreshold dose of AM251 (120 ng/rat) reversed the amnesia induced by ACPA (0.006 μg/rat) and RS23597 (0.01 μg/rat). None of the above doses altered the locomotor activity. In conclusion, our results suggest that the NAc-shell 5-HT4 receptors are involved in the modulation of ACPA-induced amnesia. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
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