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Effect of Hydroxyethyl Starch on Acidosis in Patients With Aluminum Phosphide Poisoning Publisher



Kafi G1 ; Akbarpour S2 ; Arefi M3 ; Behnoush B1 ; Pishkuhi MA4 ; Barzegari N3
Authors
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Authors Affiliations
  1. 1. Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Occupational Sleep Research Center (OSRC), Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Baharloo Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Pars Advanced and Minimally Invasive Medical Manners Research Center, Pars Hospital, Iran University of Medical Science, Tehran, Iran

Source: Caspian Journal of Internal Medicine Published:2019


Abstract

Background: Given the fact that various studies have reported the positive effects of hydroxyethyl starch therapy in controlling shock, this study aimed to compare the effects of hydroxyethyl starch on modifying acidosis and treating patients with aluminum phosphide poisoning. Methods: This was a randomized clinical trial that was conducted on 60 patients with aluminum phosphide poisoning. We compared the two groups of patients treated with hydroxyethyl starch and normal saline. Base excess and serum pH of arterial blood gases (ABG) were measured before and after the treatment and compared by t-test. Results: Results showed that arterial pH in the starch group and normal saline group increased by 0.13 and 0.18, respectively, and the difference between the two groups was not statistically significant. The difference in the base excess before and after treatment in the starch group and normal saline group was 6.41 and 5.39, respectively, and the difference between the two groups was not statistically significant. Changes in mean values of arterial pH after the intervention in comparison with before treatment were statistically significant (p<0.05). Conclusion: Overall, the results of the present study show that starch is at least as effective as normal saline in treating acidosis in patients poisoned with aluminum phosphide and can be used instead of normal saline, and both of the two treatments could be equally effective. © 2019 Babol University of Medical Sciences. All rights reserved.
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